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mmpL11 transmembrane transport protein MmpL11 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886750, updated on 6-Oct-2023

Summary

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Gene symbol
mmpL11
Gene description
transmembrane transport protein MmpL11
Locus tag
Rv0202c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (238392..241292, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene oxidoreductase Neighboring gene zinc metalloprotease Neighboring gene membrane protein Neighboring gene transmembrane protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence. Wright CC, et al. Infect Immun, 2017 Aug. PMID 28507063, Free PMC Article
  2. The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. Owens CP, et al. J Biol Chem, 2013 Jul 26. PMID 23760277, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results suggest that MmpL11 and its cell wall lipid substrates are important for survival in the context of adaptive immune pressure and for nonreplicating persistence, both of which are critically important aspects of M. tuberculosis pathogenicity
    Title: The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence.
  2. Data indicate that Rv0203 transfers heme to both MmpL3-E1 and MmpL11-E1 domains at a rate faster than passive heme dissociation from Rv0203.
    Title: The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
transmembrane transport protein MmpL11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    238392..241292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214716.1 transmembrane transport protein MmpL11 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214716.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E9A738
    Conserved Domains (1) summary
    COG2409
    Location:1 → 898
    YdfJ; Uncharacterized membrane protein YdfJ, MMPL/SSD domain [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJT9.1

Gene LinkOut

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