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msrA peptide methionine sulfoxide reductase MsrA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886865, updated on 6-Oct-2023

Summary

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Gene symbol
msrA
Gene description
peptide methionine sulfoxide reductase MsrA
Locus tag
Rv0137c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (164712..165260, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene epoxide hydrolase EphF Neighboring gene transcriptional regulator Neighboring gene cytochrome P450 Cyp138 Neighboring gene hypothetical protein Neighboring gene oxidoreductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A molecular dynamics and quantum mechanics/molecular mechanics study of the catalytic reductase mechanism of methionine sulfoxide reductase A: formation and reduction of a sulfenic acid. Dokainish HM, et al. Biochemistry, 2013 Mar 12. PMID 23418817
  2. Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite. Lee WL, et al. Mol Microbiol, 2009 Feb. PMID 19040639, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. active site residues including an aspartyl (Asp87) near the recycling cysteine, tyrosyls (Tyr44 and Tyr92), and glutamyl (Glu52), have been examined, as well as the effects of the protein and active site on the nature of mechanistic intermediates
    Title: A molecular dynamics and quantum mechanics/molecular mechanics study of the catalytic reductase mechanism of methionine sulfoxide reductase A: formation and reduction of a sulfenic acid.
  2. MsrA has a different stereospecificity than MsrB.
    Title: Mycobacterium tuberculosis expresses methionine sulphoxide reductases A and B that protect from killing by nitrite and hypochlorite.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
peptide methionine sulfoxide reductase MsrA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    164712..165260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214651.1 peptide methionine sulfoxide reductase MsrA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214651.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A654T908
    Conserved Domains (1) summary
    PRK14054
    Location:2 → 166
    PRK14054; peptide-methionine (S)-S-oxide reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WJM5.1

Gene LinkOut

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