U.S. flag

An official website of the United States government

CCKBR cholecystokinin B receptor [ Homo sapiens (human) ]

Gene ID: 887, updated on 4-Jan-2025

Summary

Official Symbol
CCKBRprovided by HGNC
Official Full Name
cholecystokinin B receptorprovided by HGNC
Primary source
HGNC:HGNC:1571
See related
Ensembl:ENSG00000110148 MIM:118445; AllianceGenome:HGNC:1571
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GASR; CCK-B; CCK2R; CCK-2R
Summary
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
Expression
Biased expression in stomach (RPKM 4.6), brain (RPKM 2.9) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CCKBR in Genome Data Viewer
Location:
11p15.4
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6259838..6272127)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6318278..6330559)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6281068..6293357)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FHF complex subunit HOOK interacting protein 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3098 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6256113-6256803 Neighboring gene MPRA-validated peak1186 silencer Neighboring gene cyclic nucleotide gated channel subunit alpha 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:6291386-6292585 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:6324771-6325489 Neighboring gene uncharacterized LOC101927825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6340407-6341144 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4339 Neighboring gene caveolae associated protein 3 Neighboring gene uncharacterized LOC124902623 Neighboring gene Sharpr-MPRA regulatory region 11421

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle  
is_active_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  

General protein information

Preferred Names
gastrin/cholecystokinin type B receptor
Names
CCK-B receptor
CCK2 receptor
cholecystokinin type 2 receptor
cholecystokinin-2 receptor
gastrin receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030591.2 RefSeqGene

    Range
    5002..17291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318029.2NP_001304958.1  gastrin/cholecystokinin type B receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC022762, AC068733
    Consensus CDS
    CCDS81550.1
    UniProtKB/TrEMBL
    E9PIC8
    Related
    ENSP00000432079.1, ENST00000532715.5
    Conserved Domains (2) summary
    pfam00001
    Location:52306
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:60159
    7tm_4; Olfactory receptor
  2. NM_001363552.2NP_001350481.1  gastrin/cholecystokinin type B receptor isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022762, AC068733, AF441129
    Consensus CDS
    CCDS86175.1
    Related
    ENSP00000435534.1, ENST00000525462.1
    Conserved Domains (2) summary
    cd14964
    Location:5781
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:55470
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_176875.4NP_795344.1  gastrin/cholecystokinin type B receptor isoform 1

    See identical proteins and their annotated locations for NP_795344.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC022762, AC068733
    Consensus CDS
    CCDS7761.1
    UniProtKB/Swiss-Prot
    A8K7P9, O75824, P32239, Q16144, Q92492, Q96LC6, Q9NYK7, Q9UBV1
    Related
    ENSP00000335544.2, ENST00000334619.7
    Conserved Domains (2) summary
    cd14964
    Location:5781
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:55401
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6259838..6272127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6318278..6330559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.