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lpqY trehalose ABC transporter substrate-binding lipoprotein LpqY [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887145, updated on 4-Feb-2024

Summary

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Gene symbol
lpqY
Gene description
trehalose ABC transporter substrate-binding lipoprotein LpqY
Locus tag
Rv1235
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1377524..1378930)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene transmembrane protein Neighboring gene sugar ABC transporter permease SugA Neighboring gene sugar ABC transporter permease SugB Neighboring gene sugar ABC transporter ATP-binding protein SugC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity. Sharma D, et al. Acta Crystallogr D Struct Biol, 2022 Jul 1. PMID 35775983
  2. Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter. Furze CM, et al. J Biol Chem, 2021 Jan-Jun. PMID 33476646, Free PMC Article
  3. Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis. Kalscheuer R, et al. Proc Natl Acad Sci U S A, 2010 Dec 14. PMID 21118978, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity.
    Title: Structural analysis of LpqY, a substrate-binding protein from the SugABC transporter of Mycobacterium tuberculosis, provides insights into its trehalose specificity.
  2. Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter.
    Title: Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter.
  3. Data show that the LpqY-SugA-SugB-SugC ATP-binding cassette transporter is a recycling system mediating the retrograde transport of released trehalose.
    Title: Trehalose-recycling ABC transporter LpqY-SugA-SugB-SugC is essential for virulence of Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
trehalose ABC transporter substrate-binding lipoprotein LpqY

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1377524..1378930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215751.1 trehalose ABC transporter substrate-binding lipoprotein LpqY [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215751.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3L7V3, A0AA36LYI9
    Conserved Domains (1) summary
    cl21456
    Location:67 → 461
    Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WGU9.1

Gene LinkOut

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Molecular Biology Databases