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rpiB ribose-5-phosphate isomerase B [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887225, updated on 4-Apr-2024

Summary

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Gene symbol
rpiB
Gene description
ribose-5-phosphate isomerase B
Locus tag
Rv2465c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2767671..2768159, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene esterase/lipase LipP Neighboring gene DNA glycosylase Neighboring gene hypothetical protein Neighboring gene aminopeptidase PepN

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase B reveal new information about the reaction mechanism. Roos AK, et al. J Biol Chem, 2005 Feb 25. PMID 15590681
  2. D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not. Roos AK, et al. J Mol Biol, 2008 Oct 10. PMID 18640127
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data describe kinetic studies examining the allose-6-phosphate isomerase activity of RpiB from Mycobacterium tuberculosis and Escherichia coli, and show that only the E. coli enzyme can catalyze the reaction efficiently.
    Title: D-ribose-5-phosphate isomerase B from Escherichia coli is also a functional D-allose-6-phosphate isomerase, while the Mycobacterium tuberculosis enzyme is not.
  2. X-ray structures of RpiB in complex with inhibitors allowed assignment of roles for most active site residues; a lysine residue in RpiAs provides for more efficient stabilization of the intermediate than the corresponding uncharged groups of RpiBs
    Title: Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase B reveal new information about the reaction mechanism.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
ribose-5-phosphate isomerase B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2767671..2768159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177884.1 ribose-5-phosphate isomerase B [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177884.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3LFZ5
    Conserved Domains (1) summary
    PRK05571
    Location:4 → 150
    PRK05571; ribose-5-phosphate isomerase B; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2VVO_A.1
2VVO_B.1
2VVO_C.1
2VVO_D.1
2VVO_E.1
2VVP_A.1
2VVP_B.1
2VVP_C.1
2VVP_D.1
2VVP_E.1
2VVQ_A.1
2VVQ_B.1
2VVQ_C.1
2VVQ_D.1
2VVQ_E.1
P9WKD7.1

Gene LinkOut

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