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trpD anthranilate phosphoribosyltransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887681, updated on 6-Oct-2023

Summary

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Gene symbol
trpD
Gene description
anthranilate phosphoribosyltransferase
Locus tag
Rv2192c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2455631..2456743, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene endopeptidase Neighboring gene hypothetical protein Neighboring gene cytochrome C oxidase subunit III Neighboring gene ubiquinol-cytochrome C reductase cytochrome subunit C Neighboring gene ubiquinol-cytochrome C reductase rieske iron-sulfur subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site. Cookson TV, et al. Biochemistry, 2015 Oct 6. PMID 26356348
  2. Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis. Cookson TV, et al. Biochem J, 2014 Jul 1. PMID 24712732
  3. The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition. Castell A, et al. Biochemistry, 2013 Mar 12. PMID 23363292
  4. The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate. Lee CE, et al. J Mol Biol, 2006 Jan 27. PMID 16337227
  5. Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design. Evans GL, et al. Biochim Biophys Acta Proteins Proteom, 2018 Feb. PMID 28844746

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The AnPRT structures presented herein indicated that PRPP binds a surface cleft and becomes enclosed due to re-positioning of two mobile loops.
    Title: Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.
  2. Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
    Title: Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
  3. AnPRT exhibits a broad substrate tolerance. Analysis of the crystal structures of the enzyme in complex with alternative substrates illuminates some details of the reaction mechanism.
    Title: Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
  4. PRPP is bound at the base of a deep cleft in anthranilate phosphoribosyltransferase and predicts two anthranilate binding sites along the tunnel leading to the PRPP binding site.
    Title: The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition.
  5. structure of TrpD from M.tuberculosis was solved by X-ray crystallography, at 1.9 A resolution for the native enzyme (R = 0.191, Rfree = 0.230) and at 2.3 A resolution for the complex with its substrate phosphoribosylpyrophosphate (PRPP)[TrpD]
    Title: The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
anthranilate phosphoribosyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2455631..2456743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216708.1 anthranilate phosphoribosyltransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216708.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E8W551, A0A109SY01
    Conserved Domains (1) summary
    PRK00188
    Location:25 → 369
    trpD; anthranilate phosphoribosyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WFX5.1

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Research Materials