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murD UDP-N-acetylmuramoylalanine--D-glutamate ligase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888000, updated on 6-Oct-2023

Summary

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Gene symbol
murD
Gene description
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Locus tag
Rv2155c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2414934..2416394, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene cell division protein FtsQ Neighboring gene UDP-N-acetylmuramate--alanine ligase Neighboring gene UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase Neighboring gene lipid II flippase FtsW Neighboring gene phospho-N-acetylmuramoyl-pentappeptidetransferase Neighboring gene UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase Neighboring gene UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ability of PknA, a mycobacterial eukaryotic-type serine/threonine kinase, to transphosphorylate MurD, a ligase involved in the process of peptidoglycan biosynthesis. Thakur M, et al. Biochem J, 2008 Oct 1. PMID 18557704
  2. Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis. Munshi T, et al. PLoS One, 2013. PMID 23555903, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of mycobacterial MurD and corynebacterial MurC synthetases is via phosphorylation and data found that all of the Mur synthetases interacted with the Ser/Thr protein kinases, PknA and PknB.
    Title: Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis.
  2. The results of the present study therefore point towards the possibility of mMurD being a substrate of PknA.
    Title: Ability of PknA, a mycobacterial eukaryotic-type serine/threonine kinase, to transphosphorylate MurD, a ligase involved in the process of peptidoglycan biosynthesis.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
UDP-N-acetylmuramoylalanine--D-glutamate ligase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2414934..2416394 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216671.3 UDP-N-acetylmuramoylalanine--D-glutamate ligase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216671.3

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655BHB9
    Conserved Domains (1) summary
    PRK03369
    Location:1 → 486
    murD; UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase
Nucleotide Protein
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