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ddlA D-alanine--D-alanine ligase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888415, updated on 6-Oct-2023

Summary

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Gene symbol
ddlA
Gene description
D-alanine--D-alanine ligase
Locus tag
Rv2981c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
ddl
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Genomic context

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Sequence:
NC_000962.3 (3336796..3337917, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transposase Neighboring gene resolvase Neighboring gene hypothetical protein Neighboring gene glycerol-3-phosphate dehydrogenase Neighboring gene 2-phospho-L-lactate guanylyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine. Prosser GA, et al. FEBS J, 2013 Feb. PMID 23286234
  2. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  3. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  4. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP is the first substrate to bind Mycobacterium tuberculosis D-alanine:D-alanine ligase and is necessary for subsequent binding of D-alanine.
    Title: Kinetic mechanism and inhibition of Mycobacterium tuberculosis D-alanine:D-alanine ligase by the antibiotic D-cycloserine.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
D-alanine--D-alanine ligase
NP_217497.1
  • D-alanylalanine synthetase (D-ala-D-ala ligase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3336796..3337917 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217497.1 D-alanine--D-alanine ligase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217497.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E8U2E5, A0A109SZR0
    Conserved Domains (1) summary
    PRK01966
    Location:17 → 367
    ddl; D-alanine--D-alanine ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WP31.1

Gene LinkOut

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Molecular Biology Databases