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dlaT pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888777, updated on 6-Oct-2023

Summary

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Gene symbol
dlaT
Gene description
pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase
Locus tag
Rv2215
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (2481965..2483626)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene cytosol aminopeptidase Neighboring gene oxidoreductase EphD Neighboring gene epimerase family protein Neighboring gene octanoyltransferase Neighboring gene lipoyl synthase Neighboring gene transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis. Shi S, et al. Infect Immun, 2006 Jan. PMID 16368957, Free PMC Article
  2. Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes. Tian J, et al. Mol Microbiol, 2005 Aug. PMID 16045627
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DlaT (dihydrolipoamide acyltransferase) and Lpd (lipoamide dehydrogenase) join with AceE to constitute pyruvate dehyrogenase[DlaT]
    Title: Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
  2. Inactivation of dlaT in the chromosome of H37Rv results in a mutant (H37RvDeltadlaT) that displays phenotypes associated with DlaT's role in metabolism and in defense against nitrosative stress.
    Title: Dihydrolipoamide acyltransferase is critical for Mycobacterium tuberculosis pathogenesis.
  3. E2 component of pyruvate dehydrogenase complex
    Title: Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2481965..2483626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216731.1 pyruvate dehydrogenase E2 component dihydrolipoamide acyltransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216731.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M7L3
    Conserved Domains (1) summary
    TIGR02927
    Location:1 → 553
    SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIS7.1

Gene LinkOut

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