Cox17 cytochrome c oxidase copper chaperone COX17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cox17provided by RGD
Official Full Name: cytochrome c oxidase copper chaperone COX17provided by RGD
Primary source: RGD:620548
See related: AllianceGenome:RGD:620548
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable copper chaperone activity; cuprous ion binding activity; and enzyme activator activity. Involved in brain development and heart development. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial intermembrane space. Orthologous to human COX17 (cytochrome c oxidase copper chaperone COX17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 544.8), Muscle (RPKM 242.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (75906245..75912036, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (62400733..62406507, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (64962663..64968437, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.
Title: COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper chaperone activity	IBA Inferred from Biological aspect of Ancestor more info
enables copper chaperone activity	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables cuprous ion binding	ISO Inferred from Sequence Orthology more info
enables enzyme activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial cytochrome c oxidase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial cytochrome c oxidase assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial intermembrane space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: COX17 homolog, cytochrome c oxidase assembly protein

Names: COX17 cytochrome c oxidase assembly homolog; COX17 cytochrome c oxidase copper chaperone; cytochrome c oxidase assembly homolog 17; cytochrome c oxidase, subunit XVII assembly protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053540.2 → NP_445992.1 COX17 homolog, cytochrome c oxidase assembly protein

See identical proteins and their annotated locations for NP_445992.1

Status: VALIDATED

Source sequence(s)

AB032178, BI293817, BQ195675

UniProtKB/TrEMBL

Q76MV3

Conserved Domains (1) summary

pfam05051
Location:18 → 63

COX17; Cytochrome C oxidase copper chaperone (COX17)