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CCRL2 C-C motif chemokine receptor like 2 [ Homo sapiens (human) ]

Gene ID: 9034, updated on 11-Apr-2024

Summary

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Official Symbol
CCRL2provided by HGNC
Official Full Name
C-C motif chemokine receptor like 2provided by HGNC
Primary source
HGNC:HGNC:1612
See related
Ensembl:ENSG00000121797 MIM:608379; AllianceGenome:HGNC:1612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCR; CKRX; CRAM; ACKR5; CRAM-A; CRAM-B
Summary
This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Expression
Broad expression in appendix (RPKM 6.4), lung (RPKM 6.3) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (46407259..46409523)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (46422959..46425353)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46448750..46451014)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine receptor 2 Neighboring gene CCR5 antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14288 Neighboring gene NANOG hESC enhancer GRCh37_chr3:46421718-46422219 Neighboring gene C-C motif chemokine receptor 5 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46434353-46434852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14289 Neighboring gene long intergenic non-protein coding RNA 2009 Neighboring gene Sharpr-MPRA regulatory region 12992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46484307-46484808 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46491889-46492388 Neighboring gene lactotransferrin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46497203-46497704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46497705-46498204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:46511713-46512212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46519415-46519916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:46519917-46520416

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2. Islam S, et al. Brief Bioinform, 2021 Jul 20. PMID 33253374
  2. CRAM-A indicates IFN-γ-associated inflammatory response in breast cancer. Sarmadi P, et al. Mol Immunol, 2015 Dec. PMID 26563945
  3. The human chemokine receptor CCRL2 suppresses chemotaxis and invasion by blocking CCL2-induced phosphorylation of p38 MAPK in human breast cancer cells. Wang LP, et al. Med Oncol, 2015 Nov. PMID 26487662
  4. Elevated chemokine CC-motif receptor-like 2 (CCRL2) promotes cell migration and invasion in glioblastoma. Yin F, et al. Biochem Biophys Res Commun, 2012 Dec 14. PMID 23142225
  5. Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia. An P, et al. PLoS Genet, 2011 Oct. PMID 22046140, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
    Title: Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function.
  2. Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1.
    Title: Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1.
  3. C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2.
    Title: C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2.
  4. The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
    Title: The Atypical Receptor CCRL2 Is Essential for Lung Cancer Immune Surveillance.
  5. CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 mRNA levels were positively correlated with inflammation, fibrosis and NASH scores in the patients.
    Title: Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men.
  6. CCRL2 inhibited the growth of breast cancer cells in vitro and in vivo.
    Title: The human chemokine receptor CCRL2 suppresses chemotaxis and invasion by blocking CCL2-induced phosphorylation of p38 MAPK in human breast cancer cells.
  7. in breast cancer, CRAM-A becomes specifically upregulated under inflammatory stimuli and may serve as a potential marker of immune response.
    Title: CRAM-A indicates IFN-γ-associated inflammatory response in breast cancer.
  8. these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion.
    Title: Elevated chemokine CC-motif receptor-like 2 (CCRL2) promotes cell migration and invasion in glioblastoma.
  9. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect pneumocystis pneumonia through immune regulation and inducing inflammation.
    Title: Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study implicates PARD3B-based AIDS restriction.
EBI GWAS Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of chemokine (C-C motif) receptor-like 2 (CCRL2) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ55815, MGC34104, MGC116710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CCR chemokine receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chemokine receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables chemokine receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemotaxis TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C-C chemokine receptor-like 2
Names
atypical chemokine receptor 5
chemokine (C-C motif) receptor-like 2
chemokine receptor CCR11
chemokine receptor X
putative MCP-1 chemokine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130910.2 → NP_001124382.1  C-C chemokine receptor-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001124382.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1, resulting in a longer isoform (2) that has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC098613, AF015524, AK296673
    Consensus CDS
    CCDS46814.1
    UniProtKB/Swiss-Prot
    O00421
    Related
    ENSP00000349967.4, ENST00000357392.4
    Conserved Domains (1) summary
    PHA03087
    Location:34 → 333
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

  2. NM_003965.5 → NP_003956.2  C-C chemokine receptor-like 2 isoform 1

    See identical proteins and their annotated locations for NP_003956.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript but encodes the longer isoform (1).
    Source sequence(s)
    AF015525, BC071682
    Consensus CDS
    CCDS43079.1
    UniProtKB/Swiss-Prot
    B4DKQ8, O00421, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
    UniProtKB/TrEMBL
    A0A024R2R2, A8MXI2, B2R8C0
    Related
    ENSP00000381994.3, ENST00000399036.4
    Conserved Domains (1) summary
    PHA03087
    Location:22 → 321
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    46407259..46409523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534208.2 → XP_011532510.1  C-C chemokine receptor-like 2 isoform X1

    See identical proteins and their annotated locations for XP_011532510.1

    UniProtKB/Swiss-Prot
    B4DKQ8, O00421, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
    UniProtKB/TrEMBL
    A0A024R2R2, A8MXI2, B2R8C0
    Related
    ENSP00000383678.2, ENST00000400882.2
    Conserved Domains (1) summary
    PHA03087
    Location:22 → 321
    PHA03087; G protein-coupled chemokine receptor-like protein; Provisional

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    46422959..46425353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348324.1 → XP_054204299.1  C-C chemokine receptor-like 2 isoform X1

    UniProtKB/Swiss-Prot
    B4DKQ8, O00421, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
    UniProtKB/TrEMBL
    A0A024R2R2, A8MXI2, B2R8C0

  2. XM_054348325.1 → XP_054204300.1  C-C chemokine receptor-like 2 isoform X1

    UniProtKB/Swiss-Prot
    B4DKQ8, O00421, O75307, Q4VBB0, Q6IPX0, Q7KYQ9, Q96KP5, Q9UPG0
    UniProtKB/TrEMBL
    A0A024R2R2, A8MXI2, B2R8C0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O00421.2 GenPept UniProtKB/Swiss-Prot:O00421

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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