Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
Molecular interactions of CD2 with LFA-3 and CD28 with B7-1 in conjunction with TCR occupancy prevent T cells from programmed apoptosis mediated by binding of CD4 to HIV-1 gp120, resulting in increased levels of IL-2 and IL-4 secretion from the T cells |
PubMed
|
|
env
|
Preincubation of T cells with HIV-1 gp120 accelerates the apoptosis observed during CD2-pathway stimulation of the T cells; this process is mediated by Fas/Fas ligand interaction and related to an increased induction of Fas ligand mRNA by gp120 |
PubMed
|
Envelope transmembrane glycoprotein gp41
|
env
|
HIV-1 gp41 peptide (amino acids 581-597) inhibits lymphoproliferation stimulated via the T-cell-activation molecules CD3, CD2, and CD28, as well as via direct stimulation mediated by phorbol ester combined with ionomycin |
PubMed
|
capsid
|
gag
|
Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to SRC |
PubMed
|
|
gag
|
Peptides corresponding to amino acids 218-238 of HIV-1 Capsid inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation |
PubMed
|
|
gag
|
Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen |
PubMed
|
nucleocapsid
|
gag
|
HIV-1 NC downregulates CD2 in HEK 293T cells |
PubMed
|
Go to the HIV-1, Human Interaction Database