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GTF3C3 general transcription factor IIIC subunit 3 [ Homo sapiens (human) ]

Gene ID: 9330, updated on 5-May-2024

Summary

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Official Symbol
GTF3C3provided by HGNC
Official Full Name
general transcription factor IIIC subunit 3provided by HGNC
Primary source
HGNC:HGNC:4666
See related
Ensembl:ENSG00000119041 MIM:604888; AllianceGenome:HGNC:4666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TFIIIC102; TFIIICgamma; TFiiiC2-102
Summary
The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in testis (RPKM 7.9), thyroid (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

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See GTF3C3 in Genome Data Viewer
Location:
2q33.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (196763035..196799683, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (197246743..197283354, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (197627759..197664407, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 150 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene uncharacterized LOC100130452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16914 Neighboring gene chromosome 2 open reading frame 66 Neighboring gene post-GPI attachment to proteins inositol deacylase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12206

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Influenza A virus matrix protein 1 interacts with hTFIIIC102-s, a short isoform of the polypeptide 3 subunit of human general transcription factor IIIC. Huang S, et al. Arch Virol, 2009. PMID 19521658
  2. Human lymphocyte cDNA ordered library analyzed by 2D gel electrophoresis. 3. Analysis of individual clones. Béhar G, et al. Appl Theor Electrophor, 1995. PMID 8573604
  3. Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates. Mertens C, et al. Mol Cell Biol, 2008 Sep. PMID 18644873, Free PMC Article
  4. Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors. Sinn E, et al. Genes Dev, 1995 Mar 15. PMID 7729686
  5. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Zhan Y, et al. Cell Death Differ, 2002 Apr. PMID 11965497

See all (107) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DEDD and FLAME-3 form nuclear complexes with TFIIIC102
    Title: Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of general transcription factor IIIC, polypeptide 3 (GTF3C3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to DNA binding IC
Inferred by Curator
more info
 PubMed 
enables RNA polymerase III general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 5S class rRNA transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in tRNA transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription by RNA polymerase III IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
part_of transcription factor TFIIIC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
general transcription factor 3C polypeptide 3
Names
TF3C-gamma
TFIIIC 102 kDa subunit
general transcription factor IIIC, polypeptide 3, 102kDa
transcription factor IIIC subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030373.1 RefSeqGene

    Range
    5086..41734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206774.2 → NP_001193703.1  general transcription factor 3C polypeptide 3 isoform 2

    See identical proteins and their annotated locations for NP_001193703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple exons from the 3' end and has an alternate 3' segment, compared to variant 1. The resulting isoform (2) has a much shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC012486, AF465407, DB078021
    Consensus CDS
    CCDS56153.1
    UniProtKB/Swiss-Prot
    Q9Y5Q9
    Related
    ENSP00000386465.3, ENST00000409364.3
    Conserved Domains (2) summary
    sd00006
    Location:183 → 211
    TPR; TPR repeat [structural motif]
    cl26002
    Location:145 → 346
    TPR_11; TPR repeat

  2. NM_012086.5 → NP_036218.1  general transcription factor 3C polypeptide 3 isoform 1

    See identical proteins and their annotated locations for NP_036218.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC012486, AK314718
    Consensus CDS
    CCDS2316.1
    UniProtKB/Swiss-Prot
    Q4ZG48, Q86XJ8, Q8WX84, Q96B44, Q9H5I8, Q9NT97, Q9Y5Q9
    Related
    ENSP00000263956.3, ENST00000263956.8
    Conserved Domains (4) summary
    smart00028
    Location:812 → 842
    TPR; Tetratricopeptide repeats
    sd00006
    Location:183 → 211
    TPR; TPR repeat [structural motif]
    pfam13414
    Location:216 → 280
    TPR_11; TPR repeat
    pfam13432
    Location:425 → 489
    TPR_16; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    196763035..196799683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246965.5 → XP_005247022.1  general transcription factor 3C polypeptide 3 isoform X1

    Conserved Domains (3) summary
    smart00028
    Location:420 → 450
    TPR; Tetratricopeptide repeats
    sd00006
    Location:30 → 57
    TPR; TPR repeat [structural motif]
    pfam13432
    Location:33 → 97
    TPR_16; Tetratricopeptide repeat

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    197246743..197283354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344614.1 → XP_054200589.1  general transcription factor 3C polypeptide 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5Q9.1 GenPept UniProtKB/Swiss-Prot:Q9Y5Q9

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