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Dach2 dachshund family transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 93837, updated on 12-May-2024

Summary

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Official Symbol
Dach2provided by MGI
Official Full Name
dachshund family transcription factor 2provided by MGI
Primary source
MGI:MGI:1890446
See related
Ensembl:ENSMUSG00000025592 AllianceGenome:MGI:1890446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9430028N04Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within development of primary female sexual characteristics. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb; and sensory organ. Orthologous to human DACH2 (dachshund family transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Dach2 in Genome Data Viewer
Location:
X E1; X 49.13 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (112207177..112746083)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (113297496..113836386)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene microRNA 361 Neighboring gene CHM Rab escort protein Neighboring gene STARR-seq mESC enhancer starr_47784 Neighboring gene STARR-seq mESC enhancer starr_47785 Neighboring gene STARR-seq mESC enhancer starr_47786 Neighboring gene Ras-GTPase-activating protein SH3-domain binding protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47787 Neighboring gene predicted gene, 24831 Neighboring gene STARR-seq mESC enhancer starr_47789 Neighboring gene STARR-seq mESC enhancer starr_47790 Neighboring gene predicted gene, 23985 Neighboring gene STARR-seq mESC enhancer starr_47791 Neighboring gene STARR-seq mESC enhancer starr_47792 Neighboring gene pyruvate kinase, muscle pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pax3 and Dach2 positive regulation in the developing somite. Kardon G, et al. Dev Dyn, 2002 Jul. PMID 12112464
  2. Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade. Tang H, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17075071, Free PMC Article
  3. Dach2-Hdac9 signaling regulates reinnervation of muscle endplates. Macpherson PC, et al. Development, 2015 Dec 1. PMID 26483211, Free PMC Article
  4. A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Tang H, et al. Mol Biol Cell, 2009 Feb. PMID 19109424, Free PMC Article
  5. Characterization of mouse Dach2, a homologue of Drosophila dachshund. Davis RJ, et al. Mech Dev, 2001 Apr. PMID 11287190

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dach2 and Hdac9 mediate the effects of muscle activity on muscle reinnervation; Myog and Gdf5 appear to stimulate muscle reinnervation through parallel pathways
    Title: Dach2-Hdac9 signaling regulates reinnervation of muscle endplates.
  2. With Dach1, may redundantly control female reproductive tract formation by regulating expression of target genes required for development of the Mullerian duct.
    Title: Mouse Dach1 and Dach2 are redundantly required for Müllerian duct development.
  3. HDAC4 is a neural activity-regulated deacetylase and a key signaling component that relays neural activity to the muscle transcriptional machinery through Dach2, myogenin, and nAChR
    Title: The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.
  4. a HDAC-Dach2-myogenin signaling pathway has been identified to decode nerve activity and control muscle gene expression in developing and adult skeletal muscle
    Title: Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade.
  5. Unlike Drosophila dachshund mutants that lack eyes and exhibit leg truncations, the eyes and limbs of Dach double mutants are present, suggesting differences between Dach and dachshund gene function during embryonic eye and limb formation.
    Title: Mouse Dach2 mutants do not exhibit gross defects in eye development or brain function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within development of primary female sexual characteristics IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dachshund homolog 2
Names
Dach2fiveprime
Dach2threeprime
dachshund 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142570.1 → NP_001136042.1  dachshund homolog 2 isoform 1

    See identical proteins and their annotated locations for NP_001136042.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK020442, AK045154, BB175077, BC059233
    Consensus CDS
    CCDS53175.1
    UniProtKB/Swiss-Prot
    Q925Q8
    Related
    ENSMUSP00000109009.2, ENSMUST00000113382.8
    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

  2. NM_001289732.1 → NP_001276661.1  dachshund homolog 2 isoform 3

    See identical proteins and their annotated locations for NP_001276661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has a distinct N- and C-terminus, compared to isoform 1.
    Source sequence(s)
    AK033050, AK041446
    Consensus CDS
    CCDS81163.1
    UniProtKB/Swiss-Prot
    Q925Q8
    Related
    ENSMUSP00000109007.2, ENSMUST00000113380.8

  3. NM_001289733.1 → NP_001276662.1  dachshund homolog 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK020442, AK033050, AK038687, AK041446, BC059233
    Consensus CDS
    CCDS81164.1
    UniProtKB/TrEMBL
    B1AU60
    Related
    ENSMUSP00000109006.2, ENSMUST00000113379.8

  4. NM_001289734.1 → NP_001276663.1  dachshund homolog 2 isoform 5

    See identical proteins and their annotated locations for NP_001276663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 5) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK033050, AK041446, AK042401
    Consensus CDS
    CCDS81165.1
    UniProtKB/TrEMBL
    B1AXA6
    Related
    ENSMUSP00000109005.2, ENSMUST00000113378.8

  5. NM_033605.2 → NP_291083.1  dachshund homolog 2 isoform 2

    See identical proteins and their annotated locations for NP_291083.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the 5' coding region and uses a different segment for its 3' coding region and UTR, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AK041446, AK045154, AL672062
    Consensus CDS
    CCDS30363.1
    UniProtKB/Swiss-Prot
    Q8BMA0, Q925Q8
    Related
    ENSMUSP00000064393.5, ENSMUST00000067219.5
    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    112207177..112746083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251527.2 → XP_030107387.1  dachshund homolog 2 isoform X10

    Conserved Domains (1) summary
    pfam02437
    Location:28 → 127
    Ski_Sno; SKI/SNO/DAC family

  2. XM_011247714.2 → XP_011246016.1  dachshund homolog 2 isoform X9

    See identical proteins and their annotated locations for XP_011246016.1

    Conserved Domains (1) summary
    pfam02437
    Location:28 → 127
    Ski_Sno; SKI/SNO/DAC family

  3. XM_011247713.4 → XP_011246015.1  dachshund homolog 2 isoform X4

    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

  4. XM_030251523.2 → XP_030107383.1  dachshund homolog 2 isoform X1

    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

  5. XM_030251524.2 → XP_030107384.1  dachshund homolog 2 isoform X6

    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

  6. XM_011247711.4 → XP_011246013.1  dachshund homolog 2 isoform X2

    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

  7. XM_030251525.2 → XP_030107385.1  dachshund homolog 2 isoform X7

    Conserved Domains (2) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family
    pfam09731
    Location:355 → 597
    Mitofilin; Mitochondrial inner membrane protein

  8. XM_030251528.2 → XP_030107388.1  dachshund homolog 2 isoform X12

    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

  9. XM_030251526.2 → XP_030107386.1  dachshund homolog 2 isoform X8

    UniProtKB/Swiss-Prot
    Q8BMA0, Q925Q8
    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

  10. XM_036162128.1 → XP_036018021.1  dachshund homolog 2 isoform X18

  11. XM_011247716.3 → XP_011246018.1  dachshund homolog 2 isoform X13

    See identical proteins and their annotated locations for XP_011246018.1

    UniProtKB/Swiss-Prot
    Q925Q8

  12. XM_036162124.1 → XP_036018017.1  dachshund homolog 2 isoform X15

    UniProtKB/TrEMBL
    B1AXA6

  13. XM_036162127.1 → XP_036018020.1  dachshund homolog 2 isoform X17

  14. XM_036162126.1 → XP_036018019.1  dachshund homolog 2 isoform X16

  15. XM_011247715.1 → XP_011246017.1  dachshund homolog 2 isoform X9

    See identical proteins and their annotated locations for XP_011246017.1

    Conserved Domains (1) summary
    pfam02437
    Location:28 → 127
    Ski_Sno; SKI/SNO/DAC family

  16. XM_036162125.1 → XP_036018018.1  dachshund homolog 2 isoform X15

    UniProtKB/TrEMBL
    B1AXA6

  17. XM_030251529.2 → XP_030107389.1  dachshund homolog 2 isoform X14

  18. XM_011247712.3 → XP_011246014.1  dachshund homolog 2 isoform X3

    Conserved Domains (1) summary
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family

  19. XM_036162123.1 → XP_036018016.1  dachshund homolog 2 isoform X5

    Conserved Domains (1) summary
    cd21081
    Location:73 → 167
    DHD_Dac; Dachshund-homology domain found in the retinal determination protein Dachshund and similar proteins

  20. XM_006528416.4 → XP_006528479.1  dachshund homolog 2 isoform X11

    Conserved Domains (2) summary
    pfam01576
    Location:474 → 571
    Myosin_tail_1; Myosin tail
    pfam02437
    Location:69 → 168
    Ski_Sno; SKI/SNO/DAC family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925Q8.1 GenPept UniProtKB/Swiss-Prot:Q925Q8

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