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Mrpl1 mitochondrial ribosomal protein L1 [ Mus musculus (house mouse) ]

Gene ID: 94061, updated on 5-Mar-2024

Summary

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Official Symbol
Mrpl1provided by MGI
Official Full Name
mitochondrial ribosomal protein L1provided by MGI
Primary source
MGI:MGI:2137202
See related
Ensembl:ENSMUSG00000029486 AllianceGenome:MGI:2137202
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L1mt; 2410002L03Rik; 5830418D04Rik
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL1 (mitochondrial ribosomal protein L1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.0), liver E14 (RPKM 3.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrpl1 in Genome Data Viewer
Location:
5 E3; 5 47.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (96357357..96414586)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (96209498..96266727)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_13673 Neighboring gene ornithine decarboxylase, structural 1 pseudogene Neighboring gene CCR4-NOT transcription complex, subunit 6-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:96589986-96590095 Neighboring gene STARR-positive B cell enhancer mm9_chr5:96592485-96592786 Neighboring gene STARR-positive B cell enhancer ABC_E2159 Neighboring gene STARR-positive B cell enhancer mm9_chr5:96638970-96639271 Neighboring gene STARR-positive B cell enhancer ABC_E10331 Neighboring gene STARR-positive B cell enhancer ABC_E6348 Neighboring gene STARR-seq mESC enhancer starr_13674 Neighboring gene STARR-seq mESC enhancer starr_13675 Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene predicted gene, 33050 Neighboring gene predicted gene, 52781

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069
  2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621
  5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL1m
Names
39S ribosomal protein L1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039084.1 → NP_001034173.1  large ribosomal subunit protein uL1m isoform 2

    See identical proteins and their annotated locations for NP_001034173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK017938, BX527348
    Consensus CDS
    CCDS51567.1
    UniProtKB/TrEMBL
    Q9D3F3
    Related
    ENSMUSP00000112451.2, ENSMUST00000121477.2
    Conserved Domains (1) summary
    cl00322
    Location:102 → 244
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

  2. NM_053158.3 → NP_444388.2  large ribosomal subunit protein uL1m isoform 1

    See identical proteins and their annotated locations for NP_444388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132243, AI462572, AK142249
    Consensus CDS
    CCDS19449.1
    UniProtKB/Swiss-Prot
    Q3UQP5, Q8K351, Q99N96, Q9CWW4
    Conserved Domains (1) summary
    cl00322
    Location:102 → 244
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    96357357..96414586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535292.2 → XP_006535355.1  large ribosomal subunit protein uL1m isoform X1

    See identical proteins and their annotated locations for XP_006535355.1

    UniProtKB/Swiss-Prot
    Q3UQP5, Q8K351, Q99N96, Q9CWW4
    Related
    ENSMUSP00000112977.2, ENSMUST00000117766.8
    Conserved Domains (1) summary
    cl00322
    Location:102 → 244
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

  2. XM_011249596.3 → XP_011247898.1  large ribosomal subunit protein uL1m isoform X2

    Conserved Domains (1) summary
    cl00322
    Location:20 → 162
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...

RNA

  1. XR_004942590.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99N96.2 GenPept UniProtKB/Swiss-Prot:Q99N96

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