Strn3 striatin, calmodulin binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Strn3provided by MGI
Official Full Name: striatin, calmodulin binding protein 3provided by MGI
Primary source: MGI:MGI:2151064
See related: Ensembl:ENSMUSG00000020954 AllianceGenome:MGI:2151064
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gs2na; SG2NA
Summary: Predicted to enable armadillo repeat domain binding activity; calmodulin binding activity; and enzyme binding activity. Predicted to be involved in negative regulation of intracellular estrogen receptor signaling pathway; regulation of transcription by RNA polymerase II; and response to estradiol. Predicted to be located in several cellular components, including Golgi apparatus; neuronal cell body; and nucleoplasm. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in dendrite. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human STRN3 (striatin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 20.8), bladder adult (RPKM 19.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 B3; 12 22.11 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (51655324..51743942, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (51608541..51692351, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.
Title: Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia.
Ectopic expression of 35 kDa and knocking down of 78 kDa SG2NAs induce cytoskeletal reorganization, alter membrane sialylation, and modulate the markers of EMT.
Title: Ectopic expression of 35 kDa and knocking down of 78 kDa SG2NAs induce cytoskeletal reorganization, alter membrane sialylation, and modulate the markers of EMT.
In cells depleted from striatin, calmodulin binding protein 3 (SG2NA) by shRNA, the levels of glycogen synthase kinase 3 beta (pGSK3beta) and pERK are reduced, suggesting that these kinases and SG2NA regulate each other's expression.
Title: GSK3β and ERK regulate the expression of 78 kDa SG2NA and ectopic modulation of its level affects phases of cell cycle.
Cell cycle analysis suggested that while loss of SG2NA reduces the level of cyclin D1 and retains a population of cells in the G1 phase, concurrent ER stress facilitates their exit from G1 and traverse through subsequent phases with concomitant cell death. Thus, SG2NA is a component of intrinsic regulatory pathways that maintains ER homeostasis
Title: SG2NA is a regulator of endoplasmic reticulum (ER) homeostasis as its depletion leads to ER stress.
results demonstrate that XBP1 mRNA splicing plays an important role in maintaining the function of bone marrow-derived macrophages and provide new insight into the study and treatment of atherosclerosis
Title: SG2NA enhances cancer cell survival by stabilizing DJ-1 and thus activating Akt.
SG2NA associates with the antioxidant protein DJ-1 and the survival kinase Akt resulting in resistance to apoptosis induced by oxidative stress.
Title: SG2NA recruits DJ-1 and Akt into the mitochondria and membrane to protect cells from oxidative damage.
Results suggest a highly versatile and dynamic mode of regulation of SG2NA with potential implications in tissue development.
Title: Tissue specific expression of SG2NA is regulated by differential splicing, RNA editing and differential polyadenylation.
Taken together, splicing variation of SG2NA might have some critical roles in differentiation and maturation in metazoan cells.
Title: WD-40 repeat protein SG2NA has multiple splice variants with tissue restricted and growth responsive properties.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236842

09.MMHAP15FLC3.seq (e-PCR)
- UniSTS:122965

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: striatin-3

Names: cell cycle autoantigen SG2NA; nuclear autoantigen; s/G2 antigen; striatin-3 35 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172098.1 → NP_001165569.1 striatin-3 isoform 2

See identical proteins and their annotated locations for NP_001165569.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two alternate in-frame exons in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK040913, AK164967, AK164987, BB821090, BC138055

Consensus CDS

CCDS49063.1

UniProtKB/TrEMBL

B2RQS1

Related

ENSMUSP00000130184.2, ENSMUST00000169503.4

Conserved Domains (4) summary

COG2319
Location:381 → 710

WD40; WD40 repeat [General function prediction only]

cd00200
Location:390 → 711

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 190

Striatin; Striatin family

sd00039
Location:400 → 446

7WD40; WD40 repeat [structural motif]
NM_001364437.1 → NP_001351366.1 striatin-3 isoform 3

Status: VALIDATED

Source sequence(s)

AC158404, AC159644

Conserved Domains (3) summary

cd00200
Location:437 → 758

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:447 → 493

7WD40; WD40 repeat [structural motif]

pfam08232
Location:64 → 190

Striatin; Striatin family
NM_052973.2 → NP_443205.1 striatin-3 isoform 1

See identical proteins and their annotated locations for NP_443205.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF307777, AK040913, AK164967, AK164987, BB821090, BC138055

Consensus CDS

CCDS36440.1

UniProtKB/Swiss-Prot

Q9ERG2

Related

ENSMUSP00000013130.9, ENSMUST00000013130.15

Conserved Domains (4) summary

COG2319
Location:465 → 794

WD40; WD40 repeat [General function prediction only]

cd00200
Location:474 → 795

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:64 → 190

Striatin; Striatin family

sd00039
Location:484 → 530

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

51655324..51743942 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157706.1 → XP_036013599.1 striatin-3 isoform X5

Conserved Domains (3) summary

cd00200
Location:391 → 712

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:401 → 447

7WD40; WD40 repeat [structural motif]

pfam08232
Location:65 → 190

Striatin; Striatin family
XM_006516411.5 → XP_006516474.1 striatin-3 isoform X3

Conserved Domains (3) summary

cd00200
Location:428 → 749

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:438 → 484

7WD40; WD40 repeat [structural motif]

pfam08232
Location:64 → 190

Striatin; Striatin family
XM_006516412.5 → XP_006516475.1 striatin-3 isoform X4

Conserved Domains (3) summary

cd00200
Location:427 → 748

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:437 → 483

7WD40; WD40 repeat [structural motif]

pfam08232
Location:64 → 190

Striatin; Striatin family
XM_036157705.1 → XP_036013598.1 striatin-3 isoform X2

Conserved Domains (3) summary

cd00200
Location:484 → 805

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:494 → 540

7WD40; WD40 repeat [structural motif]

pfam08232
Location:65 → 190

Striatin; Striatin family
XM_036157704.1 → XP_036013597.1 striatin-3 isoform X1

Conserved Domains (3) summary

cd00200
Location:531 → 852

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:541 → 587

7WD40; WD40 repeat [structural motif]

pfam08232
Location:65 → 190

Striatin; Striatin family