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dapB 4-hydroxy-tetrahydrodipicolinate reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944762, updated on 2-May-2024

Summary

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Gene symbol
dapB
Gene description
4-hydroxy-tetrahydrodipicolinate reductase
Primary source
ASAP:ABE-0000112
Locus tag
b0031
See related
ECOCYC:EG10206
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0032
Summary
A dapB mutant is not in the Keio collection; DAP auxotrophs require added DAP to grow and since no DAP was added during mutant construction, no auxotrophic mutants were recovered; dapB is not an essential gene (Baba, 2006). [More information is available at EcoGene: EG10206].
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Genomic context

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Sequence:
NC_000913.3 (28374..29195)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 4-hydroxy-3-methylbut-2-enyl diphosphate reductase Neighboring gene ribonucleoside hydrolase RihC Neighboring gene carbamoyl-phosphate synthetase small subunit Neighboring gene carbamoyl-phosphate synthetase large subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase. Devenish SR, et al. J Med Chem, 2010 Jun 24. PMID 20503968
  2. Expression, purification, and characterization of Escherichia coli dihydrodipicolinate reductase. Reddy SG, et al. Biochemistry, 1995 Mar 21. PMID 7893644
  3. Cloning of fragments of lambda dapB2 DNA and identification of the dapB gene product. Mackie GA. J Biol Chem, 1980 Sep 25. PMID 6251070
  4. Nucleotide sequence and expression of the Escherichia coli dapB gene. Bouvier J, et al. J Biol Chem, 1984 Dec 10. PMID 6094578
  5. Dihydrodipicolinic acid reductase. Tamir H, et al. J Biol Chem, 1974 May 25. PMID 4151489

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair.
    Title: Degradation of the Escherichia coli Essential Proteins DapB and Dxr Results in Oxidative Stress, which Contributes to Lethality through Incomplete Base Excision Repair.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4-hydroxy-tetrahydrodipicolinate reductase IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxy-tetrahydrodipicolinate reductase IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4-hydroxy-tetrahydrodipicolinate reductase IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in diaminopimelate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within diaminopimelate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in diaminopimelate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within diaminopimelate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
4-hydroxy-tetrahydrodipicolinate reductase
NP_414572.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    28374..29195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414572.1 4-hydroxy-tetrahydrodipicolinate reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414572.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827Y3L1
    Conserved Domains (1) summary
    COG0289
    Location:6 → 270
    DapB; Dihydrodipicolinate reductase [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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