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dapD tetrahydrodipicolinate succinylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944862, updated on 2-May-2024

Summary

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Gene symbol
dapD
Gene description
tetrahydrodipicolinate succinylase
Primary source
ASAP:ABE-0000565
Locus tag
b0166
See related
ECOCYC:EG10207
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0164; ssa
Summary
A dapD mutant is not in the Keio collection; DAP auxotrophs require added DAP to grow and since no DAP was added during mutant construction, no auxotrophic mutants were recovered; dapD is not an essential gene (Baba, 2006). [More information is available at EcoGene: EG10207]. Tetrahydrodipicolinate succinylase catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate, and is a key enzyme in the Escherichia coli lysine biosynthetic pathway. [More information is available at EcoCyc: EG10207].
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Genomic context

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Sequence:
NC_000913.3 (185123..185947, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF3461 domain-containing protein YaeH Neighboring gene phosphodiesterase YaeI Neighboring gene protein-PII uridylyltransferase/uridylyl-removing enzyme Neighboring gene methionine aminopeptidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of Escherichia coli tetrahydrodipicolinate N-succinyltransferase reveals the role of a conserved C-terminal helix in cooperative substrate binding. Nguyen L, et al. FEBS Lett, 2008 Mar 5. PMID 18242192
  2. Purification and characterization of succinyl-CoA: tetrahydrodipicolinate N-succinyltransferase from Escherichia coli. Simms SA, et al. J Biol Chem, 1984 Mar 10. PMID 6365916
  3. Regulation of expression and nucleotide sequence of the Escherichia coli dapD gene. Richaud C, et al. J Biol Chem, 1984 Dec 10. PMID 6094577
  4. Development of stable, genetically well-defined conditionally viable Escherichia coli strains. Degryse E. Mol Gen Genet, 1991 May. PMID 1646386
  5. An intracellular iron chelator pleiotropically suppresses enzymatic and growth defects of superoxide dismutase-deficient Escherichia coli. Maringanti S, et al. J Bacteriol, 1999 Jun. PMID 10368155, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in diaminopimelate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in diaminopimelate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within diaminopimelate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lysine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lysine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lysine biosynthetic process via diaminopimelate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetrahydrodipicolinate succinylase
NP_414708.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    185123..185947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414708.1 tetrahydrodipicolinate succinylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414708.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7YHW7
    Conserved Domains (1) summary
    PRK11830
    Location:1 → 271
    dapD; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional
Nucleotide Protein
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