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hemB porphobilinogen synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945017, updated on 23-Nov-2023

Summary

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Gene symbol
hemB
Gene description
porphobilinogen synthase
Primary source
ASAP:ABE-0001266
Locus tag
b0369
See related
ECOCYC:EG10428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0366; ncf
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Genomic context

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Sequence:
NC_000913.3 (388753..389727, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene taurine ABC transporter ATP binding subunit Neighboring gene taurine ABC transporter membrane subunit Neighboring gene taurine dioxygenase Neighboring gene pseudo Neighboring gene protein YtiB Neighboring gene IS3 element protein InsF Neighboring gene IS3 element protein InsE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Escherichia coli expression-based method for heme substitution. Woodward JJ, et al. Nat Methods, 2007 Jan. PMID 17187078
  2. X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 A resolution. Erskine PT, et al. Biochemistry, 1999 Apr 6. PMID 10194344
  3. Purification and characterization of 5-aminolaevulinic acid dehydratase from Escherichia coli and a study of the reactive thiols at the metal-binding domain. Spencer P, et al. Biochem J, 1993 Feb 15. PMID 8439296, Free PMC Article
  4. Porphobilinogen synthase from Escherichia coli is a Zn(II) metalloenzyme stimulated by Mg(II). Mitchell LW, et al. Arch Biochem Biophys, 1993 Jan. PMID 8424649
  5. Characterization of the role of the stimulatory magnesium of Escherichia coli porphobilinogen synthase. Jaffe EK, et al. Biochemistry, 1995 Jan 10. PMID 7819203

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Purification and characterization of 5-aminolaevulinic acid dehydratase from Escherichia coli and a study of the reactive thiols at the metal-binding domain.
  2. The Porphobilinogen synthase (PBGS) is as an enzyme that may exhibit phylogenetic diversity in its chemical reaction mechanism.
    Title: The porphobilinogen synthase catalyzed reaction mechanism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables porphobilinogen synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables porphobilinogen synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables porphobilinogen synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables porphobilinogen synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
porphobilinogen synthase
NP_414903.4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    388753..389727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414903.4 porphobilinogen synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414903.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6BLR2
    Conserved Domains (1) summary
    PRK09283
    Location:1 → 319
    PRK09283; porphobilinogen synthase
Nucleotide Protein
Heading Accession and Version

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