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aroL shikimate kinase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945031, updated on 2-May-2024

Summary

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Gene symbol
aroL
Gene description
shikimate kinase 2
Primary source
ASAP:ABE-0001353
Locus tag
b0388
See related
ECOCYC:EG10082
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0383
Summary
Expression of the structural gene of one of the coli shikimate kinase isoenzyme, the aroL gene product is regulated by the tyrR gene product protein with tyrosine or tryptophan as co-repressor. [More information is available at EcoCyc: EG10082].
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Genomic context

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Sequence:
NC_000913.3 (406405..406929)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyrroline-5-carboxylate reductase Neighboring gene DUF188 domain-containing protein YaiI Neighboring gene protein YaiA Neighboring gene protein AroM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA looping. Schleif R. Science, 1988 Apr 8. PMID 3353710
  2. A reassessment of the relationship between aroK- and aroL-encoded shikimate kinase enzymes of Escherichia coli. Whipp MJ, et al. J Bacteriol, 1995 Mar. PMID 7883721, Free PMC Article
  3. Purification and properties of shikimate kinase II from Escherichia coli K-12. DeFeyter RC, et al. J Bacteriol, 1986 Jan. PMID 3001029, Free PMC Article
  4. Aromatic amino acid biosynthesis: regulation of shikimate kinase in Escherichia coli K-12. Ely B, et al. J Bacteriol, 1979 Jun. PMID 222728, Free PMC Article
  5. Naturally occurring adenines within mRNA coding sequences affect ribosome binding and expression in Escherichia coli. Brock JE, et al. J Bacteriol, 2007 Jan. PMID 17085569, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: The cloning and expression of the aroL gene from Escherichia coli K12. Purification and complete amino acid sequence of shikimate kinase II, the aroL-gene product.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables shikimate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables shikimate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables shikimate kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in aromatic amino acid family biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within aromatic amino acid family biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chorismate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
shikimate kinase 2
NP_414922.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    406405..406929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414922.1 shikimate kinase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414922.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8H9T1E0
    Conserved Domains (1) summary
    PRK03731
    Location:1 → 170
    aroL; shikimate kinase AroL
Nucleotide Protein
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Other Literature Sources
Molecular Biology Databases
Research Materials