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mscK potassium dependent, small conductance mechanosensitive channel [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945132, updated on 2-May-2024

Summary

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Gene symbol
mscK
Gene description
potassium dependent, small conductance mechanosensitive channel
Primary source
ASAP:ABE-0001613
Locus tag
b0465
See related
ECOCYC:G6255
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
aefA; ECK0459; kefA
Summary
Consistently co-purifies with the degradosome. [More information is available at EcoGene: EG14240]. MscK, the potassium-dependent mechanosensitive (MS) channel of small conductance, is one of four classes of E.coli MS channels. [More information is available at EcoCyc: G6255].
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Genomic context

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Sequence:
NC_000913.3 (486536..489898)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrA Neighboring gene DNA-binding transcriptional repressor AcrR Neighboring gene DUF2496 domain-containing protein YbaM Neighboring gene primosomal replication protein N''

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of mutations that alter the gating of the Escherichia coli mechanosensitive channel protein, MscK. Li C, et al. Mol Microbiol, 2007 Apr. PMID 17493135, Free PMC Article
  2. Identification of N-acetylgalactosamine-containing glycoproteins PEB3 and CgpA in Campylobacter jejuni. Linton D, et al. Mol Microbiol, 2002 Jan. PMID 11985725
  3. Effect of mutation of potassium-efflux system, KefA, on mechanosensitive channels in the cytoplasmic membrane of Escherichia coli. Cui C, et al. J Membr Biol, 1996 Mar. PMID 8661775
  4. Characterization of mechanosensitive channels in Escherichia coli cytoplasmic membrane by whole-cell patch clamp recording. Cui C, et al. J Membr Biol, 1995 Mar. PMID 7595939
  5. Concentration dependent effect of GsMTx4 on mechanosensitive channels of small conductance in E. coli spheroplasts. Hurst AC, et al. Eur Biophys J, 2009 Apr. PMID 19132368

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular water homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to potassium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
potassium dependent, small conductance mechanosensitive channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    486536..489898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414998.1 potassium dependent, small conductance mechanosensitive channel [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414998.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3P5DMK2
    Conserved Domains (1) summary
    PRK11281
    Location:7 → 1120
    PRK11281; mechanosensitive channel MscK
Nucleotide Protein
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