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ubiF 3-demethoxyubiquinol 3-hydroxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945261, updated on 4-Apr-2024

Summary

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Gene symbol
ubiF
Gene description
3-demethoxyubiquinol 3-hydroxylase
Primary source
ASAP:ABE-0002265
Locus tag
b0662
See related
ECOCYC:G6365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0654; yleB
Summary
visC, ubiH, ubiF and mhpA are paralogs. [More information is available at EcoGene: EG13658]. 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase catalyzes the third monooxygenase reaction in the ubiquinone biosynthesis pathway. [More information is available at EcoCyc: G6365].
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Genomic context

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Sequence:
NC_000913.3 (695101..696276)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene endoribonuclease YbeY Neighboring gene PhoH-like protein Neighboring gene isopentenyl-adenosine A37 tRNA methylthiolase Neighboring gene tRNA-Gln Neighboring gene tRNA-Gln

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a respiratory mutant of Escherichia coli with reduced uptake of aminoglycoside antibiotics. Muir ME, et al. Biochim Biophys Acta, 1981 Dec 14. PMID 7032590
  2. An Escherichia coli mutant resistant to phleomycin, bleomycin, and heat inactivation is defective in ubiquinone synthesis. Collis CM, et al. J Bacteriol, 1989 Sep. PMID 2475481, Free PMC Article
  3. Energy production genes sucB and ubiF are involved in persister survival and tolerance to multiple antibiotics and stresses in Escherichia coli. Ma C, et al. FEMS Microbiol Lett, 2010 Feb. PMID 20041955
  4. Complementation of Escherichia coli ubiF mutation by Caenorhabditis elegans CLK-1, a product of the longevity gene of the nematode worm. Adachi A, et al. FEBS Lett, 2003 May 22. PMID 12753928
  5. Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone. Young IG, et al. J Bacteriol, 1971 Mar. PMID 4323297, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. sucB and ubiF mutants deficient in energy production were identified from the mutant screens to have defective persister survival as demonstrated by higher susceptibility to various antibiotics and different stresses.
    Title: Energy production genes sucB and ubiF are involved in persister survival and tolerance to multiple antibiotics and stresses in Escherichia coli.
  2. 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase
    Title: Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-demethoxyubiquinol 3-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-demethoxyubiquinol 3-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-demethoxyubiquinol 3-hydroxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquinone biosynthesis complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3-demethoxyubiquinol 3-hydroxylase
NP_415195.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    695101..696276
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415195.1 3-demethoxyubiquinol 3-hydroxylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415195.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA87JUS7
    Conserved Domains (1) summary
    PRK08020
    Location:1 → 391
    ubiF; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed
Nucleotide Protein
Heading Accession and Version

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