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arnC undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945275, updated on 2-May-2024

Summary

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Gene symbol
arnC
Gene description
undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
Primary source
ASAP:ABE-0007458
Locus tag
b2254
See related
ECOCYC:G7167
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2247; pmrF; yfbF
Summary
Involved in the modification of lipid A phosphates with aminoarabinose that is required for polymyxin B and cationic antimicrobial peptide resistance. [More information is available at EcoGene: EG14090]. ArnC is an undecaprenyl transferase that acts in a pathway which modifies lipid A phosphates with 4-amino-4-deoxy-L-arabinose (L-Ara4N), causing increased resistance to polymyxin . [More information is available at EcoCyc: G7167].
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Genomic context

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Sequence:
NC_000913.3 (2367071..2368039)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipopolysaccharide core heptose(II)-phosphate phosphatase Neighboring gene UDP-4-amino-4-deoxy-L-arabinose aminotransferase Neighboring gene fused UDP-4-amino-4-deoxy-L-arabinose formyltransferase/UDP-glucuronate dehydrogenase Neighboring gene putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxidative decarboxylation of UDP-glucuronic acid in extracts of polymyxin-resistant Escherichia coli. Origin of lipid a species modified with 4-amino-4-deoxy-L-arabinose. Breazeale SD, et al. J Biol Chem, 2002 Jan 25. PMID 11706007
  2. A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose. Breazeale SD, et al. J Biol Chem, 2005 Apr 8. PMID 15695810
  3. Molecular basis of the magnesium deprivation response in Salmonella typhimurium: identification of PhoP-regulated genes. Soncini FC, et al. J Bacteriol, 1996 Sep. PMID 8752324, Free PMC Article
  4. Lipopolysaccharides of polymyxin B-resistant mutants of Escherichia coli are extensively substituted by 2-aminoethyl pyrophosphate and contain aminoarabinose in lipid A. Nummila K, et al. Mol Microbiol, 1995 Apr. PMID 7565089
  5. Lipid A modifications characteristic of Salmonella typhimurium are induced by NH4VO3 in Escherichia coli K12. Detection of 4-amino-4-deoxy-L-arabinose, phosphoethanolamine and palmitate. Zhou Z, et al. J Biol Chem, 1999 Jun 25. PMID 10373459

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase
NP_416757.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2367071..2368039
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416757.1 undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416757.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A831GQ32
    Conserved Domains (1) summary
    PRK10714
    Location:3 → 321
    PRK10714; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
Nucleotide Protein
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