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rfbB dTDP-glucose 4,6-dehydratase 1 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945276, updated on 23-Nov-2023

Summary

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Gene symbol
rfbB
Gene description
dTDP-glucose 4,6-dehydratase 1
Primary source
ASAP:ABE-0006766
Locus tag
b2041
See related
ECOCYC:EG12412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2035; rmlB; som
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Genomic context

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Sequence:
NC_000913.3 (2111976..2113061, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene polyisoprenol-linked O16-antigen repeat unit flippase Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene glucose-1-phosphate thymidylyltransferase 1 Neighboring gene dTDP-4-dehydrorhamnose reductase Neighboring gene UTP:glucose-1-phosphate uridylyltransferase, low activity Neighboring gene putative colanic acid biosynthesis protein WcaM

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Function of rmlB in the pathogenic Escherichia coli 44277 (O2: k1)]. Ding W, et al. Wei Sheng Wu Xue Bao, 2011 Sep. PMID 22126071
  2. Biological mechanisms involved in the formation of deoxy sugars. IV. Enzymatic conversion of thymidine diphosphoglucose-4T to thymidine diphospho-4-keto-6-deoxyglucose-6T. Gabriel O, et al. J Biol Chem, 1968 Apr 10. PMID 4869561
  3. The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase. Melo A, et al. J Biol Chem, 1968 Apr 10. PMID 4869560
  4. The mechanism of 6-deoxyhexose synthesis. V. The relation of pyridine nucleotide to the structure of the deoxythymidine diphosphate-glucose oxidoreductase. Zarkowsky H, et al. J Biol Chem, 1970 Dec 25. PMID 4320607
  5. Biological mechanisms involved in the formation of deoxysugars. VI. Role and function of enzyme-bound nicotinamide adenine dinucleotide in thymidine diphosphate D-glucose oxidoreductase. Wang SF, et al. J Biol Chem, 1970 Jan 10. PMID 4312478

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RmlB has the activity of dTDP-D-glucose 4,6-dehydratase but it is not essential for the synthesis of L-rhamnose.
    Title: [Function of rmlB in the pathogenic Escherichia coli 44277 (O2: k1)].
  2. Results showed a reproducible and clear cut classification with molecular polymorphism of rfb gene cluster and flagella gene fliC.
    Title: Molecular typing of Escherichia coli strains isolated from food in Casablanca (Morocco).
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables dTDP-glucose 4,6-dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dTDP-glucose 4,6-dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dTDP-glucose 4,6-dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables dTDP-glucose 4,6-dehydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in O antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in dTDP-rhamnose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in extracellular polysaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nucleotide-sugar biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-sugar metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dTDP-glucose 4,6-dehydratase 1
NP_416545.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2111976..2113061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416545.1 dTDP-glucose 4,6-dehydratase 1 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416545.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0A8J6R4
    Conserved Domains (1) summary
    PRK10084
    Location:1 → 352
    PRK10084; dTDP-glucose 4,6 dehydratase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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