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moeB molybdopterin-synthase adenylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945452, updated on 4-Apr-2024

Summary

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Gene symbol
moeB
Gene description
molybdopterin-synthase adenylyltransferase
Primary source
ASAP:ABE-0002820
Locus tag
b0826
See related
ECOCYC:EG10154
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
chlN; ECK0816
Summary
Molybdenum and tungsten cofactors of all enzymes, with the exception of nitrogenase, that require one or the other of the other for activity are present in an oxidized state as molybdate or tungstate ions that are chelated by the cis-dithiolene moiety of a molybdenum cofactor. [More information is available at EcoCyc: EG10154].
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Genomic context

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Sequence:
NC_000913.3 (864380..865129, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative pyruvate formate-lyase activating enzyme YbiY Neighboring gene fructose-6-phosphate aldolase 1 Neighboring gene molybdopterin molybdotransferase Neighboring gene isoaspartyl dipeptidase proenzyme Neighboring gene glutathione ABC transporter ATP binding subunit GsiA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nitrate reductase activity and heterocyst suppression on nitrate in Anabaena sp. strain PCC 7120 require moeA. Ramaswamy KS, et al. J Bacteriol, 1996 Jul. PMID 8682795, Free PMC Article
  2. Reconstitution of plant nitrate reductase by Escherichia coli extracts and the molecular cloning of the chlA gene of Escherichia coli K12. Taylor JL, et al. J Mol Appl Genet, 1983. PMID 6363588
  3. IscS functions as a primary sulfur-donating enzyme by interacting specifically with MoeB and MoaD in the biosynthesis of molybdopterin in Escherichia coli. Zhang W, et al. J Biol Chem, 2010 Jan 22. PMID 19946146, Free PMC Article
  4. Role of the C-terminal Gly-Gly motif of Escherichia coli MoaD, a molybdenum cofactor biosynthesis protein with a ubiquitin fold. Schmitz J, et al. Biochemistry, 2007 Jan 23. PMID 17223713
  5. Cloning and sequencing of the Escherichia coli chlEN operon involved in molybdopterin biosynthesis. Nohno T, et al. J Bacteriol, 1988 Sep. PMID 3045084, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin-synthase adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdopterin-synthase adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiosulfate sulfurtransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like modifier activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
molybdopterin-synthase adenylyltransferase
NP_415347.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    864380..865129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415347.1 molybdopterin-synthase adenylyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415347.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8H9XMY2, A0A8S7EBK3
    Conserved Domains (1) summary
    PRK05690
    Location:1 → 244
    PRK05690; molybdopterin biosynthesis protein MoeB; Provisional
Nucleotide Protein
Heading Accession and Version

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