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aqpZ water channel AqpZ [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945497, updated on 2-May-2024

Summary

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Gene symbol
aqpZ
Gene description
water channel AqpZ
Primary source
ASAP:ABE-0002976
Locus tag
b0875
See related
ECOCYC:EG13270
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
bniP; ECK0866
Summary
AqpZ-dependent water permeability increases as cells enter stationary phase. [More information is available at EcoGene: EG13270]. AqpZ is a water channel, or aquaporin, that allows bi-directional passive diffusion of water in Escherichia coli. [More information is available at EcoCyc: EG13270].
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Genomic context

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Sequence:
NC_000913.3 (915352..916047, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein S-nitrosylase Neighboring gene L-lysine/thialysine exporter Neighboring gene DUF2813 domain-containing protein YbjD Neighboring gene DUF535 domain-containing protein YbjX Neighboring gene ABC-type tripartite efflux pump membrane fusion protein Neighboring gene ABC-type tripartite efflux pump ATP binding/membrane subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy. Tan H, et al. Biochim Biophys Acta Biomembr, 2022 Feb 1. PMID 34624277
  2. Positive cooperativity in the activation of E. coli aquaporin Z by cardiolipin: Potential for lipid-based aquaporin modulators. Tan CL, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2021 May. PMID 33581256
  3. Water permeation dynamics of AqpZ: a tale of two states. Xin L, et al. Biochim Biophys Acta, 2011 Jun. PMID 21315687
  4. Structural context shapes the aquaporin selectivity filter. Savage DF, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855585, Free PMC Article
  5. Cell-free synthesis of functional aquaporin Z in synthetic liposomes. Hovijitra NT, et al. Biotechnol Bioeng, 2009 Sep 1. PMID 19557835

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy.
    Title: Dynamics properties of membrane proteins in native cell membranes revealed by solid-state NMR spectroscopy.
  2. Positive cooperativity in the activation of E. coli aquaporin Z by cardiolipin: Potential for lipid-based aquaporin modulators.
    Title: Positive cooperativity in the activation of E. coli aquaporin Z by cardiolipin: Potential for lipid-based aquaporin modulators.
  3. Induction of an immune response against AqpZ or its homologous regions can also trigger an autoimmune reaction against human Aqp4 and inflammation of the central nervous system.
    Title: Cross-immunoreactivity between bacterial aquaporin-Z and human aquaporin-4: potential relevance to neuromyelitis optica.
  4. Data show that the open and closed states of AqpZ directly relate to the side chain conformation of residue R189.
    Title: Water permeation dynamics of AqpZ: a tale of two states.
  5. biochemical analysis of permeability and solute transport characteristics of amphiphilic triblock-polymer vesicles containing the bacterial water-channel protein Aquaporin Z
    Title: Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z.
  6. analysis of of Escherichia coli aquaporin AqpZ and GlpF single-channel water permeabilities
    Title: Single-channel water permeabilities of Escherichia coli aquaporins AqpZ and GlpF.
  7. the 2.5 A resolution structure of AqpZ suggests aquaporin selectivity results both from a steric mechanism due to pore size and from specific amino acid substitutions that regulate the preference for a hydrophobic or hydrophilic substrate
    Title: Architecture and selectivity in aquaporins: 2.5 a X-ray structure of aquaporin Z.
  8. the difference in Arg-189 displacements is correlated with a strong electron density between first transmembrane helices of two open channels; the observed Arg-189 conformations are stabilized by asymmetrical subunit interactions in tAqpZ
    Title: Crystal structure of AqpZ tetramer reveals two distinct Arg-189 conformations associated with water permeation through the narrowest constriction of the water-conducting channel.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables water channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables water channel activity IEA
Inferred from Electronic Annotation
more info
  
enables water channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in water transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within water transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in water transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in water transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
water channel AqpZ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    915352..916047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415396.1 water channel AqpZ [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415396.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7IEG3
    Conserved Domains (1) summary
    PRK05420
    Location:1 → 231
    PRK05420; aquaporin Z; Provisional
Nucleotide Protein
Heading Accession and Version

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