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scpA methylmalonyl-CoA mutase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945576, updated on 2-May-2024

Summary

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Gene symbol
scpA
Gene description
methylmalonyl-CoA mutase
Primary source
ASAP:ABE-0009577
Locus tag
b2917
See related
ECOCYC:EG11444
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2913; sbm; yliK
Summary
Part of a four gene operon encoding enzymes converting succinate to propionate. [More information is available at EcoGene: EG11444]. Methylmalonyl-CoA mutase (MCM) catalyzes the reversible, stereospecific interconversion of methylmalonyl-CoA to succinyl-CoA . [More information is available at EcoCyc: EG11444].
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Genomic context

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Sequence:
NC_000913.3 (3060850..3062994)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DNA-binding transcriptional dual regulator ArgP Neighboring gene methylmalonyl-CoA mutase-interacting GTPase YgfD Neighboring gene methylmalonyl-CoA decarboxylase Neighboring gene propionyl-CoA:succinate CoA transferase Neighboring gene putative DNA-binding transcriptional regulator YgfI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HPLC assay for methylmalonyl-CoA epimerase. Bobik TA, et al. Anal Bioanal Chem, 2003 Feb. PMID 12589497
  2. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Dayem LC, et al. Biochemistry, 2002 Apr 23. PMID 11955068
  3. Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli. Froese DS, et al. Microbiol Res, 2009. PMID 18950999, Free PMC Article
  4. MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation. Korotkova N, et al. J Biol Chem, 2004 Apr 2. PMID 14734568
  5. Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar typhimurium. Aldor IS, et al. Appl Environ Microbiol, 2002 Aug. PMID 12147480, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sbm is expressed and interacts with ygfD in Escherichia coli.
    Title: Sleeping beauty mutase (sbm) is expressed and interacts with ygfd in Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables cobalamin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cobalamin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cobalamin binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylmalonyl-CoA mutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylmalonyl-CoA mutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylmalonyl-CoA mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in propionate metabolic process, methylmalonyl pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methylmalonyl-CoA mutase
NP_417392.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3060850..3062994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417392.1 methylmalonyl-CoA mutase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417392.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376TST4, A0A7L7EHC1, A0A827XVP7
    Conserved Domains (1) summary
    PRK09426
    Location:1 → 714
    PRK09426; methylmalonyl-CoA mutase; Reviewed
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials