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fabD [acyl-carrier-protein] S-malonyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945766, updated on 2-May-2024

Summary

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Gene symbol
fabD
Gene description
[acyl-carrier-protein] S-malonyltransferase
Primary source
ASAP:ABE-0003698
Locus tag
b1092
See related
ECOCYC:EG11317
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1078; tfpA
Summary
The fabD gene is part of a fatty acid biosynthesis operon and the malonyl-CoA transacylase is part of a multienzyme fatty acid synthase II complex. [More information is available at EcoCyc: EG11317].
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Genomic context

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Sequence:
NC_000913.3 (1149728..1150657)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phosphate acyltransferase Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 3 Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase FabG Neighboring gene acyl carrier protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography. Oefner C, et al. Acta Crystallogr D Biol Crystallogr, 2006 Jun. PMID 16699188
  2. A continuous coupled enzyme assay for bacterial malonyl-CoA:acyl carrier protein transacylase (FabD). Molnos J, et al. Anal Biochem, 2003 Aug 1. PMID 12842120
  3. Molecular characterization of an Escherichia coli mutant with a temperature-sensitive malonyl coenzyme A-acyl carrier protein transacylase. Verwoert II, et al. FEBS Lett, 1994 Jul 18. PMID 8034061
  4. Resistance to trifluoroperazine, a calmodulin inhibitor, maps to the fabD locus in Escherichia coli. Bouquin N, et al. Mol Gen Genet, 1995 Mar 10. PMID 7700236
  5. Studies on the mechanism of fatty acid synthesis. XXVI. Purification and properties of malonyl-coenzyme A--acyl carrier protein transacylase of Escherichia coli. Joshi VC, et al. Arch Biochem Biophys, 1971 Apr. PMID 4934182

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
    Title: Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  3. A possible new catalytic enzyme mechanism is discussed for FabD.
    Title: Mapping the active site of Escherichia coli malonyl-CoA-acyl carrier protein transacylase (FabD) by protein crystallography.
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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables [acyl-carrier-protein] S-malonyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
[acyl-carrier-protein] S-malonyltransferase
NP_415610.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1149728..1150657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415610.1 [acyl-carrier-protein] S-malonyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415610.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    D0VE86
    Conserved Domains (1) summary
    TIGR00128
    Location:2 → 292
    fabD; malonyl CoA-acyl carrier protein transacylase
Nucleotide Protein
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