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fabI enoyl-[acyl-carrier-protein] reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945870, updated on 2-May-2024

Summary

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Gene symbol
fabI
Gene description
enoyl-[acyl-carrier-protein] reductase
Primary source
ASAP:ABE-0004327
Locus tag
b1288
See related
ECOCYC:EG11528
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1283; envM; gts; qmeA
Summary
fabI is an essential gene. [More information is available at EcoGene: EG11528]. The FabI protein is an enoyl acyl carrier protein reductase which catalyzes an essential step in fatty acid biosynthesis. [More information is available at EcoCyc: EG11528].
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Genomic context

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Sequence:
NC_000913.3 (1350251..1351039, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene RNase II Neighboring gene putative peroxidase YciW Neighboring gene DUF559 domain-containing protein YcjD Neighboring gene putrescine ABC exporter ATP binding protein SapF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of lysine 2-hydroxyisobutyrylation on bacterial FabI activity and resistance to triclosan. Zheng Y, et al. Biochimie, 2021 Mar. PMID 33485933
  2. The prevalence and mechanism of triclosan resistance in Escherichia coli isolated from urine samples in Wenzhou, China. Zeng W, et al. Antimicrob Resist Infect Control, 2020 Oct 2. PMID 33008474, Free PMC Article
  3. Escherichia coli enoyl-acyl carrier protein reductase (FabI) supports efficient operation of a functional reversal of β-oxidation cycle. Vick JE, et al. Appl Environ Microbiol, 2015 Feb. PMID 25527535, Free PMC Article
  4. Novel enoyl-ACP reductase (FabI) potential inhibitors of Escherichia coli from Chinese medicine monomers. Yao J, et al. Bioorg Med Chem Lett, 2010 Jan 1. PMID 19959361
  5. Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI). Sampson PB, et al. Bioorg Med Chem Lett, 2009 Sep 15. PMID 19682901

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The prevalence and mechanism of triclosan resistance in Escherichia coli isolated from urine samples in Wenzhou, China.
    Title: The prevalence and mechanism of triclosan resistance in Escherichia coli isolated from urine samples in Wenzhou, China.
  2. Effects of lysine 2-hydroxyisobutyrylation on bacterial FabI activity and resistance to triclosan.
    Title: Effects of lysine 2-hydroxyisobutyrylation on bacterial FabI activity and resistance to triclosan.
  3. Reduced susceptibility to antiseptics is conferred by heterologous housekeeping genes, fabI and gale.
    Title: Reduced Susceptibility to Antiseptics Is Conferred by Heterologous Housekeeping Genes.
  4. FabI encodes a native enoyl-CoA reductase activity that supports the beta-oxidation reversal in E. coli.
    Title: Escherichia coli enoyl-acyl carrier protein reductase (FabI) supports efficient operation of a functional reversal of β-oxidation cycle.
  5. N-terminus verified by Edman degradation on mature peptide
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  6. crystallographic analysis of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli
    Title: Structure of acyl carrier protein bound to FabI, the FASII enoyl reductase from Escherichia coli.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADH binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables enoyl-[acyl-carrier-protein] reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enoyl-[acyl-carrier-protein] reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biotin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biotin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fatty acid elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane HDA PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
enoyl-[acyl-carrier-protein] reductase
NP_415804.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1350251..1351039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415804.1 enoyl-[acyl-carrier-protein] reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415804.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377DUN4
    Conserved Domains (1) summary
    PRK07984
    Location:1 → 262
    PRK07984; enoyl-ACP reductase FabI
Nucleotide Protein
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