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dgcM diguanylate cyclase DgcM [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945909, updated on 2-May-2024

Summary

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Gene symbol
dgcM
Gene description
diguanylate cyclase DgcM
Primary source
ASAP:ABE-0004504
Locus tag
b1341
See related
ECOCYC:G6673
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1338; ydaM
Summary
YdaM has a central PAS domain, then a C-terminal diguanylate cyclase GGDEF domain. [More information is available at EcoGene: EG13355]. YdaM controls curli biosynthesis by inducing transcription of the regulator CsgD at 28C, probably by production of the signalling molecule c-diGMP. [More information is available at EcoCyc: G6673].
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Genomic context

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Sequence:
NC_000913.3 (1406563..1407795, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA endonuclease SmrA Neighboring gene protein YnaN Neighboring gene Zn(2(+)):H(+) symporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The EAL domain protein YciR acts as a trigger enzyme in a c-di-GMP signalling cascade in E. coli biofilm control. Lindenberg S, et al. EMBO J, 2013 Jul 17. PMID 23708798, Free PMC Article
  2. Cyclic-di-GMP-mediated signalling within the sigma network of Escherichia coli. Weber H, et al. Mol Microbiol, 2006 Nov. PMID 17010156
  3. C-di-GMP: the dawning of a novel bacterial signalling system. Römling U, et al. Mol Microbiol, 2005 Aug. PMID 16045609
  4. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833
  5. The global transcriptional response of Escherichia coli to induced sigma 32 protein involves sigma 32 regulon activation followed by inactivation and degradation of sigma 32 in vivo. Zhao K, et al. J Biol Chem, 2005 May 6. PMID 15757896

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables diguanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diguanylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diguanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion involved in single-species biofilm formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of bacterial-type flagellum-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of single-species biofilm formation on inanimate substrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diguanylate cyclase DgcM
NP_415857.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1406563..1407795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415857.2 diguanylate cyclase DgcM [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415857.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8NBR8, A0A8T6AV26
    Conserved Domains (2) summary
    pfam00990
    Location:253 → 406
    GGDEF; Diguanylate cyclase, GGDEF domain
    cl21578
    Location:130 → 249
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
Nucleotide Protein
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