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paaE phenylacetyl-CoA 1,2-epoxidase, reductase subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945962, updated on 11-Apr-2024

Summary

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Gene symbol
paaE
Gene description
phenylacetyl-CoA 1,2-epoxidase, reductase subunit
Primary source
ASAP:ABE-0004657
Locus tag
b1392
See related
ECOCYC:G6713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1389; ydbR
Summary
PaaABCDE is a multi-subunit oxygenase that hydroxylates phenylacetyl-CoA. [More information is available at EcoGene: EG13739]. PaaE may be an NAD(P)H-dependent electron donor to the terminal oxygenase composed of PaaA, PaaB, and PaaC, plus a PaaD subunit , which is involved in phenylacetate catabolism . [More information is available at EcoCyc: G6713].
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Genomic context

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Sequence:
NC_000913.3 (1456430..1457500)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene phenylacetyl-CoA 1,2-epoxidase, structural subunit Neighboring gene phenylacetate degradation protein Neighboring gene putative 2,3-dehydroadipyl-CoA hydratase Neighboring gene putative ring 1,2-epoxyphenylacetyl-CoA isomerase (oxepin-CoA forming) Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene phenylacetyl-CoA thioesterase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural and functional studies of the Escherichia coli phenylacetyl-CoA monooxygenase complex. Grishin AM, et al. J Biol Chem, 2011 Mar 25. PMID 21247899, Free PMC Article
  2. Genetic characterization of the phenylacetyl-coenzyme A oxygenase from the aerobic phenylacetic acid degradation pathway of Escherichia coli. Fernández C, et al. Appl Environ Microbiol, 2006 Nov. PMID 16997993, Free PMC Article
  3. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
  4. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858
  5. Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway. Ferrández A, et al. J Biol Chem, 1998 Oct 2. PMID 9748275

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2 iron, 2 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phenylacetate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phenylacetate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
part_of phenylacetyl-CoA 1,2-epoxidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
phenylacetyl-CoA 1,2-epoxidase, reductase subunit
NP_415910.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1456430..1457500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415910.1 phenylacetyl-CoA 1,2-epoxidase, reductase subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415910.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA87H072
    Conserved Domains (1) summary
    TIGR02160
    Location:4 → 351
    PA_CoA_Oxy5; phenylacetate-CoA oxygenase/reductase, PaaK subunit
Nucleotide Protein
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