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fumC fumarase C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946147, updated on 11-Apr-2024

Summary

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Gene symbol
fumC
Gene description
fumarase C
Primary source
ASAP:ABE-0005380
Locus tag
b1611
See related
ECOCYC:EG10358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1606
Summary
SoxRS regulon. [More information is available at EcoGene: EG10358]. One of three isozymes in Escherichia coli, fumarase C is a Class II fumarase. [More information is available at EcoCyc: EG10358].
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Genomic context

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Sequence:
NC_000913.3 (1685185..1686588, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator RstA Neighboring gene sensory histidine kinase RstB Neighboring gene DNA replication terminus site-binding protein Neighboring gene fumarase A Neighboring gene mannose-6-phosphate isomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Closed fumarase C active-site structures reveal SS Loop residue contribution in catalysis. Stuttgen GM, et al. FEBS Lett, 2020 Jan. PMID 31514245
  2. Evolving dual targeting of a prokaryotic protein in yeast. Burak E, et al. Mol Biol Evol, 2013 Jul. PMID 23462316
  3. Structure of free fumarase C from Escherichia coli. Weaver T. Acta Crystallogr D Biol Crystallogr, 2005 Oct. PMID 16204892
  4. The role of the allosteric B site in the fumarase reaction. Rose IA, et al. Proc Natl Acad Sci U S A, 2004 Mar 9. PMID 14990798, Free PMC Article
  5. Mutations of fumarase that distinguish between the active site and a nearby dicarboxylic acid binding site. Weaver T, et al. Protein Sci, 1997 Apr. PMID 9098893, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we report structural and kinetic analyses from Escherichia coli FumC variants to understand the contribution of SS Loop residues S318, K324, and N326. High-resolution X-ray crystallographic results reveal three distinct FumC active-site conformations; disordered-open, ordered-open, and the newly discovered ordered-closed.
    Title: Closed fumarase C active-site structures reveal SS Loop residue contribution in catalysis.
  2. Starting with an exclusively mitochondrial targeted FumC (attached to a strong MTS), we show that two randomly acquired mutations within the prokaryotic FumC sequence are sufficient to cause substantial dual targeting by reverse translocation
    Title: Evolving dual targeting of a prokaryotic protein in yeast.
  3. The results show that Crp is an activator of fumA and fumC gene expression under various oxygen conditions and growth rates.
    Title: Regulatory role of cAMP receptor protein over Escherichia coli fumarase genes.
  4. N-terminus verified by Edman degradation on complete protein
    Title: Purification and crystallization of fumarase C from Escherichia coli.
  5. water is a permanent member of the active site of FumC, which uses an imidazole-imidazolium conversion to control access at the allosteric B site
    Title: Structure of free fumarase C from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables fumarate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fumarate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fumarate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fumarate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fumarate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of tricarboxylic acid cycle heteromeric enzyme complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fumarase C
NP_416128.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1685185..1686588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416128.1 fumarase C [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416128.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8Q991
    Conserved Domains (1) summary
    PRK00485
    Location:1 → 464
    fumC; fumarate hydratase; Reviewed
Nucleotide Protein
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