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thiB thiamine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946306, updated on 25-Jan-2024

Summary

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Gene symbol
thiB
Gene description
thiamine ABC transporter periplasmic binding protein
Primary source
ASAP:ABE-0000249
Locus tag
b0068
See related
ECOCYC:EG11574
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0069; sfuA; tbpA; yabL
Summary
thiBPQ operon expression is controlled by a thiamine pyrophosphate (TPP) responsive riboswitch in the 128 nt 5' UTR. [More information is available at EcoGene: EG11574]. The Escherichia coli SufA/TbpA protein has been purified and characterized as a 34.2 kDa monomer. [More information is available at EcoCyc: EG11574].
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Genomic context

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Sequence:
NC_000913.3 (74497..75480, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DedA family protein YabI Neighboring gene thiamine ABC transporter ATP binding subunit Neighboring gene thiamine ABC transporter membrane subunit Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator SgrR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Soriano EV, et al. Biochemistry, 2008 Feb 5. PMID 18177053, Free PMC Article
  2. Overexpression, purification, and characterization of the periplasmic space thiamin-binding protein of the thiamin traffic ATPase in Escherichia coli. Hollenbach AD, et al. Protein Expr Purif, 2002 Aug. PMID 12182833
  3. Thiamin-binding proteins. Itokawa Y, et al. Ann N Y Acad Sci, 1982. PMID 7044227
  4. [Proteins specifically binding thiamine and their biological role]. Rybina AA, et al. Ukr Biokhim Zh (1978), 1980 Sep-Oct. PMID 6789521
  5. Thiamine-binding protein of Escherichia coli. Iwashima A, et al. J Bacteriol, 1971 Dec. PMID 4945201, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables thiamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thiamine pyrophosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine pyrophosphate binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in thiamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within thiamine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thiamine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in outer membrane-bounded periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thiamine ABC transporter periplasmic binding protein
NP_414610.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    74497..75480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414610.1 thiamine ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414610.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EBT5
    Conserved Domains (1) summary
    PRK11205
    Location:13 → 327
    tbpA; thiamine transporter substrate binding subunit; Provisional
Nucleotide Protein
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