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dmlA D-malate/3-isopropylmalate dehydrogenase (decarboxylating) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946319, updated on 4-Apr-2024

Summary

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Gene symbol
dmlA
Gene description
D-malate/3-isopropylmalate dehydrogenase (decarboxylating)
Primary source
ASAP:ABE-0005991
Locus tag
b1800
See related
ECOCYC:G6986
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1798; ttuC; yeaU
Summary
AFMB Structural Genomics target Number 39 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG13507]. YeaU is a D-malate dehydrogenase that is essential for growth on D-malate as the sole carbon source . [More information is available at EcoCyc: G6986].
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Genomic context

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Sequence:
NC_000913.3 (1881912..1882997)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene leucine exporter Neighboring gene DNA-binding transcriptional regulator DmlR Neighboring gene putative transporter YeaV Neighboring gene carnitine monooxygenase subunit YeaW

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tartrate dehydrogenase catalyzes the stepwise oxidative decarboxylation of D-malate with both NAD and thio-NAD. Karsten WE, et al. Biochemistry, 2002 Oct 8. PMID 12356321
  2. Escherichia coli D-malate dehydrogenase, a generalist enzyme active in the leucine biosynthesis pathway. Vorobieva AA, et al. J Biol Chem, 2014 Oct 17. PMID 25160617, Free PMC Article
  3. Regulation of aerobic and anaerobic D-malate metabolism of Escherichia coli by the LysR-type regulator DmlR (YeaT). Lukas H, et al. J Bacteriol, 2010 May. PMID 20233924, Free PMC Article
  4. Time-dependent translational response of E. coli to excess Zn(II). Easton JA, et al. J Biomol Tech, 2006 Dec. PMID 17122063, Free PMC Article
  5. Systems approach to refining genome annotation. Reed JL, et al. Proc Natl Acad Sci U S A, 2006 Nov 14. PMID 17088549, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-isopropylmalate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-malate dehydrogenase (decarboxylating) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-malate dehydrogenase (decarboxylating) activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables tartrate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tartrate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in malate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within malate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-malate/3-isopropylmalate dehydrogenase (decarboxylating)
NP_416314.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1881912..1882997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416314.1 D-malate/3-isopropylmalate dehydrogenase (decarboxylating) [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416314.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7T8KVW9, A0AA87EUM5
    Conserved Domains (1) summary
    cl00445
    Location:2 → 359
    Iso_dh; Isocitrate/isopropylmalate dehydrogenase
Nucleotide Protein
Heading Accession and Version

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