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ftsW peptidoglycan glycosyltransferase FtsW [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946322, updated on 11-Apr-2024

Summary

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Gene symbol
ftsW
Gene description
peptidoglycan glycosyltransferase FtsW
Primary source
ASAP:ABE-0000320
Locus tag
b0089
See related
ECOCYC:EG10344
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0090
Summary
FtsW is required for mrdA(PBP2) expression. ftsW is paralogous to mrdB(rodA). ftsW is an essential gene. [More information is available at EcoGene: EG10344]. FtsW is an essential cell division protein that is conserved in most walled bacteria; the protein is produced at low levels and localizes to the septum . [More information is available at EcoCyc: EG10344].
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Genomic context

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Sequence:
NC_000913.3 (98403..99647)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-alanyl-D-alanine-adding enzyme Neighboring gene phospho-N-acetylmuramoyl-pentapeptide-transferase Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene N-acetylglucosaminyl transferase Neighboring gene UDP-N-acetylmuramate--L-alanine ligase Neighboring gene D-alanine--D-alanine ligase B Neighboring gene cell division protein FtsQ Neighboring gene cell division protein FtsA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW. Yang X, et al. Nat Microbiol, 2021 May. PMID 33495624, Free PMC Article
  2. Specificity of the transport of lipid II by FtsW in Escherichia coli. Mohammadi T, et al. J Biol Chem, 2014 May 23. PMID 24711460, Free PMC Article
  3. Identification of FtsW as a transporter of lipid-linked cell wall precursors across the membrane. Mohammadi T, et al. EMBO J, 2011 Apr 20. PMID 21386816, Free PMC Article
  4. Topological characterization of the essential Escherichia coli cell division protein FtsW. Lara B, et al. FEMS Microbiol Lett, 2002 Oct 29. PMID 12423747
  5. ftsW is an essential cell-division gene in Escherichia coli. Boyle DS, et al. Mol Microbiol, 1997 Jun. PMID 9218774

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW.
    Title: A two-track model for the spatiotemporal coordination of bacterial septal cell wall synthesis revealed by single-molecule imaging of FtsW.
  2. Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
    Title: Genetic analysis of the septal peptidoglycan synthase FtsWI complex supports a conserved activation mechanism for SEDS-bPBP complexes.
  3. Data show that the transmembrane helix 4 of membrane protein FtsW is required for the transport activity of the protein.
    Title: Specificity of the transport of lipid II by FtsW in Escherichia coli.
  4. In this work the authors show direct interactions between FtsW and PBP3 in vivo and in vitro by FRET (Forster resonance energy transfer) and co-immunoprecipitation experiments.
    Title: The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex in Escherichia coli.
  5. Data show that FtsW interact with MtgA and help MtgA's role in peptidoglycan assembly during the cell cycle.
    Title: The monofunctional glycosyltransferase of Escherichia coli localizes to the cell division site and interacts with penicillin-binding protein 3, FtsW, and FtsN.
  6. FtsW is associated in a hierarchical set of protein complexes and its assembly can occur independently of 'upstream' proteins.
    Title: Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.
  7. identification of several domains of the protein with distinct functions in cell division
    Title: Functional analysis of the cell division protein FtsW of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipid-linked peptidoglycan transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid-linked peptidoglycan transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in FtsZ-dependent cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in FtsZ-dependent cytokinesis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell division NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in division septum assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lipid-linked peptidoglycan transport IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell division site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell division site IEA
Inferred from Electronic Annotation
more info
  
located_in cell division site NAS
Non-traceable Author Statement
more info
 PubMed 
part_of divisome complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
peptidoglycan glycosyltransferase FtsW

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    98403..99647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414631.1 peptidoglycan glycosyltransferase FtsW [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414631.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A192CI42, A0A5B9ABM1, A0AA36P079, A0AA88EQG6, Q1RGA6
    Conserved Domains (1) summary
    PRK10774
    Location:11 → 414
    PRK10774; cell division protein FtsW; Provisional
Nucleotide Protein
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