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hisA 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946521, updated on 25-Jan-2024

Summary

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Gene symbol
hisA
Gene description
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
Primary source
ASAP:ABE-0006725
Locus tag
b2024
See related
ECOCYC:EG10444
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2019
Summary
N-(5'-phospho-L-ribosyl-formimino)-5-amino-1-(5'-phosphoribosyl)-4-imidazolecarboxamide isomerase (HisA) carries out the fourth step in histidine biosynthesis. [More information is available at EcoCyc: EG10444].
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Genomic context

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Sequence:
NC_000913.3 (2095125..2095862)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase Neighboring gene O-antigen co-polymerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates. Henn-Sax M, et al. Biochemistry, 2002 Oct 8. PMID 12356303
  2. A preliminary map of genomic sites for F-attachment in Escherichia coli K12. Matney TS, et al. Biochem Biophys Res Commun, 1964 Oct 14. PMID 5324449
  3. Evolution of the structure and chromosomal distribution of histidine biosynthetic genes. Fani R, et al. Orig Life Evol Biosph, 1998 Oct. PMID 9742729
  4. The role of gene fusions in the evolution of metabolic pathways: the histidine biosynthesis case. Fani R, et al. BMC Evol Biol, 2007 Aug 16. PMID 17767732, Free PMC Article
  5. Structure and function of the internal promoter (hisBp) of the Escherichia coli K-12 histidine operon. Grisolia V, et al. J Bacteriol, 1983 Sep. PMID 6309747, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within histidine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase
NP_416528.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2095125..2095862
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416528.2 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416528.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EP43
    Conserved Domains (1) summary
    PRK00748
    Location:1 → 238
    PRK00748; 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Validated
Nucleotide Protein
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