U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hisG ATP phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946549, updated on 2-May-2024

Summary

Go to the top of the page Help
Gene symbol
hisG
Gene description
ATP phosphoribosyltransferase
Primary source
ASAP:ABE-0006713
Locus tag
b2019
See related
ECOCYC:EG10449
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2014
Summary
ATP phosphoribosyltransferase (HisG) catalyzes the first step in the pathway of histidine biosynthesis. [More information is available at EcoCyc: EG10449].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (2090192..2091091)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribosome-dependent mRNA interferase toxin YoeB Neighboring gene YefM antitoxin of the YoeB-YefM toxin-antitoxin pair and DNA binding transcriptional repressor Neighboring gene his operon leader peptide Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Lohkamp B, et al. J Mol Biol, 2004 Feb 6. PMID 14741209
  2. Purification, crystallization and preliminary X-ray crystallographic analysis of ATP-phosphoribosyltransferase from Escherichia coli. Lohkamp B, et al. Acta Crystallogr D Biol Crystallogr, 2000 Nov. PMID 11185885
  3. In vivo and in vitro detection of the leader RNA of the histidine operon of Escherichia coli K-12. Frunzio R, et al. Proc Natl Acad Sci U S A, 1981 May. PMID 6166940, Free PMC Article
  4. Cold-sensitive mutants of Escherichia coli resulting from increased feedback inhibition. O'Donovan GA, et al. Proc Natl Acad Sci U S A, 1965 Aug. PMID 5324392, Free PMC Article
  5. Regulatory properties of phosphoribosyladenosine triphosphate synthetase. Synergism between adenosine monophosphate, phosphoribosyladenosine triphosphate, and histidine. Klungsoyr L, et al. Biochemistry, 1970 Apr 28. PMID 4909873

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
ATP phosphoribosyltransferase
NP_416523.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2090192..2091091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416523.1 ATP phosphoribosyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416523.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A828NCH0
    Conserved Domains (1) summary
    PRK00489
    Location:3 → 299
    hisG; ATP phosphoribosyltransferase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.