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wzzB O-antigen co-polymerase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946553, updated on 4-Feb-2024

Summary

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Gene symbol
wzzB
Gene description
O-antigen co-polymerase
Primary source
ASAP:ABE-0006731
Locus tag
b2027
See related
ECOCYC:G7090
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cld; ECK2022; rol; wzz
Summary
In Escherichia coli strains O8 and O9, the orthologous Wzz protein was shown to control the length of the O-antigen component of lipopolysaccharide . [More information is available at EcoCyc: G7090].
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Genomic context

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Sequence:
NC_000913.3 (2097321..2098301, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase Neighboring gene UDP-glucose 6-dehydrogenase Neighboring gene 6-phosphogluconate dehydrogenase, decarboxylating

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of a full-length bacterial polysaccharide co-polymerase. Wiseman B, et al. Nat Commun, 2021 Jan 14. PMID 33446644, Free PMC Article
  2. A Wzz (Cld) protein determines the chain length of K lipopolysaccharide in Escherichia coli O8 and O9 strains. Franco AV, et al. J Bacteriol, 1996 Apr. PMID 8606163, Free PMC Article
  3. Repeat unit polysaccharides of bacteria: a model for polymerization resembling that of ribosomes and fatty acid synthetase, with a novel mechanism for determining chain length. Bastin DA, et al. Mol Microbiol, 1993 Mar. PMID 7682279
  4. Regulation by a novel protein of the bimodal distribution of lipopolysaccharide in the outer membrane of Escherichia coli. Batchelor RA, et al. J Bacteriol, 1991 Sep. PMID 1715860, Free PMC Article
  5. Quaternary structure of WzzB and WzzE polysaccharide copolymerases. Kalynych S, et al. Protein Sci, 2015 Jan. PMID 25307743, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of a full-length bacterial polysaccharide co-polymerase.
    Title: Structure of a full-length bacterial polysaccharide co-polymerase.
  2. E.coli WzzB and WzzE Polysaccharide Copolymerases form octameric homo-oligomeric complexes.
    Title: Quaternary structure of WzzB and WzzE polysaccharide copolymerases.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
O-antigen co-polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2097321..2098301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416531.4 O-antigen co-polymerase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416531.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    D8A574
    Conserved Domains (1) summary
    PRK15471
    Location:1 → 326
    PRK15471; chain length determinant protein WzzB; Provisional
Nucleotide Protein
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