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rfbX polyisoprenol-linked O16-antigen repeat unit flippase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946557, updated on 23-Nov-2023

Summary

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Gene symbol
rfbX
Gene description
polyisoprenol-linked O16-antigen repeat unit flippase
Primary source
ASAP:ABE-0006757
Locus tag
b2037
See related
ECOCYC:EG11980
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2031; wzx; wzxB
Summary
RfbX, also known as WzxB, is a member of the Polysaccharide Transporter (PST) Family . [More information is available at EcoCyc: EG11980].
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Genomic context

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Sequence:
NC_000913.3 (2108337..2109584, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative O-antigen polymerase Neighboring gene UDP-galactopyranose mutase Neighboring gene dTDP-4-dehydrorhamnose 3,5-epimerase Neighboring gene glucose-1-phosphate thymidylyltransferase 1 Neighboring gene dTDP-4-dehydrorhamnose reductase Neighboring gene dTDP-glucose 4,6-dehydratase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An O-antigen processing function for Wzx (RfbX): a promising candidate for O-unit flippase. Liu D, et al. J Bacteriol, 1996 Apr. PMID 8606190, Free PMC Article
  2. The activity of a putative polyisoprenol-linked sugar translocase (Wzx) involved in Escherichia coli O antigen assembly is independent of the chemical structure of the O repeat. Feldman MF, et al. J Biol Chem, 1999 Dec 3. PMID 10574995
  3. Computer-based analyses of the protein constituents of transport systems catalysing export of complex carbohydrates in bacteria. Paulsen IT, et al. Microbiology (Reading), 1997 Aug. PMID 9274022
  4. Function of the rfb gene cluster and the rfe gene in the synthesis of O antigen by Shigella dysenteriae 1. Klena JD, et al. Mol Microbiol, 1993 Jul. PMID 7692219
  5. Sequence and analysis of the O antigen gene (rfb) cluster of Escherichia coli O111. Bastin DA, et al. Gene, 1995 Oct 16. PMID 7590310

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in O antigen biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipopolysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
polyisoprenol-linked O16-antigen repeat unit flippase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2108337..2109584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416541.1 polyisoprenol-linked O16-antigen repeat unit flippase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416541.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P37746
    Conserved Domains (1) summary
    pfam01943
    Location:8 → 278
    Polysacc_synt; Polysaccharide biosynthesis protein
Nucleotide Protein
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