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fcl GDP-L-fucose synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946563, updated on 27-Nov-2023

Summary

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Gene symbol
fcl
Gene description
GDP-L-fucose synthase
Primary source
ASAP:ABE-0006801
Locus tag
b2052
See related
ECOCYC:EG11788
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2046; wcaG; yefB
Summary
GDP-fucose synthase is a bifunctional enzyme that catalyzes the two-step synthesis of GDP-fucose from GDP-4-dehydro-6-deoxy-D-mannose via a GDP-4-dehydro-6-L-deoxygalactose intermediate . [More information is available at EcoCyc: EG11788].
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Genomic context

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Sequence:
NC_000913.3 (2126225..2127190, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene mannose-1-phosphate guanylyltransferase Neighboring gene colanic acid biosynthesis fucosyltransferase WcaI Neighboring gene GDP-mannose mannosyl hydrolase Neighboring gene GDP-mannose 4,6-dehydratase Neighboring gene colanic acid biosynthesis acetyltransferase WcaF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Studies on the biosynthesis of guanosine diphosphate L-fucose. GINSBURG V. J Biol Chem, 1961 Sep. PMID 13705522
  2. The metabolism of 6-deoxyhexoses in bacterial and animal cells. Tonetti M, et al. Biochimie, 1998 Nov. PMID 9893952
  3. GDP-fucose synthetase from Escherichia coli: structure of a unique member of the short-chain dehydrogenase/reductase family that catalyzes two distinct reactions at the same active site. Somers WS, et al. Structure, 1998 Dec 15. PMID 9862812
  4. GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from Escherichia coli, a key enzyme in the biosynthesis of GDP-L-fucose, displays the structural characteristics of the RED protein homology superfamily. Rizzi M, et al. Structure, 1998 Nov 15. PMID 9817848
  5. Preliminary crystallographic investigations of recombinant GDP-4-keto-6-deoxy-D-mannose epimerase/reductase from E. coli. Tonetti M, et al. Acta Crystallogr D Biol Crystallogr, 1998 Jul 1. PMID 9761875

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GDP-L-fucose synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-L-fucose synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-L-fucose synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP+ binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in colanic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-sugar biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GDP-L-fucose synthase
NP_416556.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2126225..2127190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416556.1 GDP-L-fucose synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416556.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A826Z187, A0A8T6BPM6
    Conserved Domains (1) summary
    cd05239
    Location:5 → 313
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs
Nucleotide Protein
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