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ndh NADH:quinone oxidoreductase II [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946792, updated on 11-Apr-2024

Summary

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Gene symbol
ndh
Gene description
NADH:quinone oxidoreductase II
Primary source
ASAP:ABE-0003746
Locus tag
b1109
See related
ECOCYC:EG10649
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1095
Summary
NADH:ubiquinone oxidoreductase II (NDH-2) is a type IIA NADH dehydrogenase that catalyzes the transfer of electrons from NADH to the quinone pool in the cytoplasmic membrane. [More information is available at EcoCyc: EG10649].
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Genomic context

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Sequence:
NC_000913.3 (1166085..1167389)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene beta-N-acetylglucosaminidase Neighboring gene PF05728 family protein YcfP Neighboring gene PF05433 family protein YcfJ Neighboring gene DNA-binding transcriptional repressor ComR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Substrate-Protein Interactions of Type II NADH:Quinone Oxidoreductase from Escherichia coli. Salewski J, et al. Biochemistry, 2016 May 17. PMID 27109164
  2. Improved poly(3-hydroxybutyrate) production in Escherichia coli by inactivation of cytochrome bd-II oxidase or/and NDH-II dehydrogenase in low efficient respiratory chains. Liu Q, et al. J Biotechnol, 2014 Dec 20. PMID 25281801
  3. Cu(II)-reduction by Escherichia coli cells is dependent on respiratory chain components. Volentini SI, et al. Biometals, 2011 Oct. PMID 21390523
  4. A critical phosphate concentration in the stationary phase maintains ndh gene expression and aerobic respiratory chain activity in Escherichia coli. Schurig-Briccio LA, et al. FEMS Microbiol Lett, 2008 Jul. PMID 18492062
  5. The Cu(II)-reductase NADH dehydrogenase-2 of Escherichia coli improves the bacterial growth in extreme copper concentrations and increases the resistance to the damage caused by copper and hydroperoxide. Rodríguez-Montelongo L, et al. Arch Biochem Biophys, 2006 Jul 1. PMID 16759635

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Because of the specific stabilization of substrate complexes of EcNDH-2 immobilized on electrodes, it was possible to demonstrate the presence of two distinct substrate binding sites for NADH and the quinone and to identify a bound semiprotonated quinol as a catalytic intermediate.
    Title: Substrate-Protein Interactions of Type II NADH:Quinone Oxidoreductase from Escherichia coli.
  2. Improved poly(3-hydroxybutyrate) production in Escherichia coli by inactivation of cytochrome bd-II oxidase or/and NDH-II dehydrogenase in low efficient respiratory chains
    Title: Improved poly(3-hydroxybutyrate) production in Escherichia coli by inactivation of cytochrome bd-II oxidase or/and NDH-II dehydrogenase in low efficient respiratory chains.
  3. The paper reports that the maintenance of NDH-2 activity and ndh expression in the stationary phase when cells were grown in media containing at least 37 mM phosphate.
    Title: A critical phosphate concentration in the stationary phase maintains ndh gene expression and aerobic respiratory chain activity in Escherichia coli.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Nucleotide sequence coding for the respiratory NADH dehydrogenase of Escherichia coli. UUG initiation codon.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NADH dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase (ubiquinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADH dehydrogenase (ubiquinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADH oxidation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within aerobic electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within anaerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NADH dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
NADH:quinone oxidoreductase II
NP_415627.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1166085..1167389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415627.1 NADH:quinone oxidoreductase II [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415627.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7YME2
    Conserved Domains (1) summary
    COG1252
    Location:6 → 423
    Ndh; NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version

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