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alaC glutamate--pyruvate aminotransferase AlaC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946850, updated on 2-May-2024

Summary

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Gene symbol
alaC
Gene description
glutamate--pyruvate aminotransferase AlaC
Primary source
ASAP:ABE-0007850
Locus tag
b2379
See related
ECOCYC:G7242
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2375; yfdZ
Summary
AFMB Structural Genomics target Number 22 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG14198]. Expression of yfdZ is activated by the transcriptional regulator SgrR. [More information is available at EcoCyc: G7242].
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Genomic context

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Sequence:
NC_000913.3 (2497057..2498295, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene palmitoleoyl acyltransferase Neighboring gene putative membrane protein YpdK Neighboring gene sensor histidine kinase PyrS Neighboring gene DNA-binding transcriptional activator PyrR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of a mutant auxotrophic for L-alanine and identification of three major aminotransferases that synthesize L-alanine in Escherichia coli. Yoneyama H, et al. Biosci Biotechnol Biochem, 2011. PMID 21597182
  2. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli. Peña-Soler E, et al. PLoS One, 2014. PMID 25014014, Free PMC Article
  3. Genetics and regulation of the major enzymes of alanine synthesis in Escherichia coli. Kim SH, et al. J Bacteriol, 2010 Oct. PMID 20729367, Free PMC Article
  4. The novel transcription factor SgrR coordinates the response to glucose-phosphate stress. Vanderpool CK, et al. J Bacteriol, 2007 Mar. PMID 17209026, Free PMC Article
  5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
    Title: Structural analysis and mutant growth properties reveal distinctive enzymatic and cellular roles for the three major L-alanine transaminases of Escherichia coli.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-alanine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-alanine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within L-alanine biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within alanine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glutamate--pyruvate aminotransferase AlaC
NP_416880.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2497057..2498295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416880.1 glutamate--pyruvate aminotransferase AlaC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416880.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N0IRZ1, A0A793GPF9
    Conserved Domains (1) summary
    PRK08175
    Location:8 → 402
    PRK08175; aminotransferase; Validated
Nucleotide Protein
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