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prpE propionyl-CoA synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946891, updated on 2-May-2024

Summary

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Gene symbol
prpE
Gene description
propionyl-CoA synthetase
Primary source
ASAP:ABE-0001154
Locus tag
b0335
See related
ECOCYC:G6200
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0332; yahU
Summary
Crp regulon. [More information is available at EcoGene: EG13604]. Acs appears to be more likely than PrpE to catalyze the first step in the propionate metabolism pathway . [More information is available at EcoCyc: G6200].
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Genomic context

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Sequence:
NC_000913.3 (352706..354592)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2-methylcitrate synthase Neighboring gene 2-methylcitrate dehydratase Neighboring gene cytosine transporter Neighboring gene cytosine/isoguanine deaminase Neighboring gene DNA-binding transcriptional dual regulator CynR

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. E. coli propionyl-CoA synthetase is regulated in vitro by an intramolecular disulfide bond. Guo Y, et al. Prikl Biokhim Mikrobiol, 2012 May-Jun. PMID 22834299
  2. The prpE gene of Salmonella typhimurium LT2 encodes propionyl-CoA synthetase. Horswill AR, et al. Microbiology (Reading), 1999 Jun. PMID 10411265
  3. Salmonella typhimurium LT2 catabolizes propionate via the 2-methylcitric acid cycle. Horswill AR, et al. J Bacteriol, 1999 Sep. PMID 10482501, Free PMC Article
  4. Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria. Textor S, et al. Arch Microbiol, 1997 Nov. PMID 9325432
  5. Oxidation of propionate to pyruvate in Escherichia coli. Involvement of methylcitrate dehydratase and aconitase. Brock M, et al. Eur J Biochem, 2002 Dec. PMID 12473114

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables propionate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables propionate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables propionate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in propionate catabolic process, 2-methylcitrate cycle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
propionyl-CoA synthetase
NP_414869.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    352706..354592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414869.1 propionyl-CoA synthetase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414869.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7H9SDU9
    Conserved Domains (1) summary
    PRK10524
    Location:1 → 628
    prpE; propionyl-CoA synthetase; Provisional
Nucleotide Protein
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Gene LinkOut

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Other Literature Sources
Molecular Biology Databases