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pbpC peptidoglycan glycosyltransferase PbpC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947152, updated on 23-Nov-2023

Summary

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Gene symbol
pbpC
Gene description
peptidoglycan glycosyltransferase PbpC
Primary source
ASAP:ABE-0008294
Locus tag
b2519
See related
ECOCYC:G7322
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2515; yfgN
Summary
PbpC has a penicillin-insensitive transglycosylase N-terminal domain. [More information is available at EcoGene: EG14210]. The PBP1C protein contains both a penicillin-binding and a transglycosylation domain. [More information is available at EcoCyc: G7322].
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Genomic context

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Sequence:
NC_000913.3 (2645013..2647325, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S rRNA m(2)A2503 methyltransferase/tRNA m(2)A37 methyltransferase Neighboring gene nucleoside diphosphate kinase Neighboring gene alpha2-macroglobulin Neighboring gene 3-mercaptopyruvate sulfurtransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Labeling pattern of major penicillin-binding proteins of Escherichia coli during the division cycle. Wientjes FB, et al. J Bacteriol, 1983 Mar. PMID 6337993, Free PMC Article
  2. Binding of latamoxef (moxalactam) and its decarboxylated derivative to Escherichia coli and Pseudomonas aeruginosa penicillin-binding proteins. Labia R, et al. J Antimicrob Chemother, 1985 Jan. PMID 3918982
  3. A simple screen for murein transglycosylase inhibitors. Vollmer W, et al. Antimicrob Agents Chemother, 2000 May. PMID 10770749, Free PMC Article
  4. Multimodular penicillin-binding proteins: an enigmatic family of orthologs and paralogs. Goffin C, et al. Microbiol Mol Biol Rev, 1998 Dec. PMID 9841666, Free PMC Article
  5. Kinship and diversification of bacterial penicillin-binding proteins and beta-lactamases. Massova I, et al. Antimicrob Agents Chemother, 1998 Jan. PMID 9449253, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables penicillin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables penicillin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables penicillin binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan glycosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidoglycan glycosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in response to antibiotic IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidoglycan glycosyltransferase PbpC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2645013..2647325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417014.1 peptidoglycan glycosyltransferase PbpC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417014.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6BF80
    Conserved Domains (1) summary
    PRK11240
    Location:3 → 770
    PRK11240; penicillin-binding protein 1C; Provisional
Nucleotide Protein
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