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mazG nucleoside triphosphate pyrophosphohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947254, updated on 23-Nov-2023

Summary

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Gene symbol
mazG
Gene description
nucleoside triphosphate pyrophosphohydrolase
Primary source
ASAP:ABE-0009117
Locus tag
b2781
See related
ECOCYC:EG10572
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2775
Summary
MazG is a nucleoside pyrophosphohydrolase that limits the deleterious effect of the MazF toxin under nutritional stress conditions . [More information is available at EcoCyc: EG10572].
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Genomic context

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Sequence:
NC_000913.3 (2909894..2910685, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene enolase Neighboring gene CTP synthetase Neighboring gene endoribonuclease toxin MazF Neighboring gene antitoxin of the MazF-MazE toxin-antitoxin system MazE Neighboring gene GDP/GTP pyrophosphokinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. House cleaning, a part of good housekeeping. Galperin MY, et al. Mol Microbiol, 2006 Jan. PMID 16359314
  2. Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions. Moroz OV, et al. J Mol Biol, 2005 Mar 25. PMID 15740738
  3. The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome. Marianovsky I, et al. J Biol Chem, 2001 Feb 23. PMID 11071896
  4. Energetics of MazG unfolding in correlation with its structural features. Drobnak I, et al. J Mol Biol, 2009 Sep 11. PMID 19523960
  5. The stationary-phase sigma factor sigma(S) is responsible for the resistance of Escherichia coli stationary-phase cells to mazEF-mediated cell death. Kolodkin-Gal I, et al. J Bacteriol, 2009 May. PMID 19251848, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside triphosphate diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside triphosphate diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleoside triphosphate diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in TTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dATP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dGTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dTTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dUTP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleoside triphosphate pyrophosphohydrolase
NP_417261.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2909894..2910685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417261.1 nucleoside triphosphate pyrophosphohydrolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417261.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A3L5H8T0, A0A6N8R0Z7, A0A828L2U8
    Conserved Domains (1) summary
    PRK09562
    Location:1 → 262
    mazG; nucleoside triphosphate pyrophosphohydrolase; Reviewed
Nucleotide Protein
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