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queF 7-cyano-7-deazaguanine reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947270, updated on 2-May-2024

Summary

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Gene symbol
queF
Gene description
7-cyano-7-deazaguanine reductase
Primary source
ASAP:ABE-0009162
Locus tag
b2794
See related
ECOCYC:G7452
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2789; yqcD
Summary
Asn, Asp, Tyr, and His tRNA GUN anticodons are modified by queuosine at the G. [More information is available at EcoGene: EG13173]. QueF catalyzes a later step of queuosine biosynthesis, the formation of preQ1 from preQ0 . [More information is available at EcoCyc: G7452].
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Genomic context

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Sequence:
NC_000913.3 (2925348..2926196)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SecY-interacting protein Neighboring gene nucleotide 5'-monophosphate nucleosidase Neighboring gene L-serine:H(+) symporter SdaC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli. Jung J, et al. J Biol Chem, 2016 Dec 2. PMID 27754868, Free PMC Article
  2. Expression and characterization of the nitrile reductase queF from E. coli. Moeller K, et al. Enzyme Microb Technol, 2013 Mar 5. PMID 23410922
  3. Possible anticodon sequences of tRNA His , tRNA Asm , and tRNA Asp from Escherichia coli B. Universal presence of nucleoside Q in the first postion of the anticondons of these transfer ribonucleic acids. Harada F, et al. Biochemistry, 1972 Jan 18. PMID 4550561
  4. Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Kasai H, et al. Biochemistry, 1975 Sep 23. PMID 1101947
  5. Three-dimensional structure of hyper-modified nucleoside Q located in the wobbling position of tRNA. Yokoyama S, et al. Nature, 1979 Nov 1. PMID 388227

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A model of QueF substrate recognition and a catalytic pathway for the enzyme are proposed based on these data.
    Title: Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli.
  2. The expression of NP-417272 after cloning in E coli BL21 cells was studied, and optimal conditions for its activity toward its natural substrate were determined.
    Title: Expression and characterization of the nitrile reductase queF from E. coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables preQ1 synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables preQ1 synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in queuosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within queuosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
7-cyano-7-deazaguanine reductase
NP_417274.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2925348..2926196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417274.1 7-cyano-7-deazaguanine reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417274.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827Y070
    Conserved Domains (1) summary
    PRK11792
    Location:9 → 282
    queF; 7-cyano-7-deazaguanine reductase; Provisional
Nucleotide Protein
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