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fucA L-fuculose-phosphate aldolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947282, updated on 11-Apr-2024

Summary

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Gene symbol
fucA
Gene description
L-fuculose-phosphate aldolase
Primary source
ASAP:ABE-0009179
Locus tag
b2800
See related
ECOCYC:EG10348
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2795; fucC; prd
Summary
FucA can function as both an L-fuculose-phosphate aldolase and a D-ribulose-phosphate aldolase, the third enzyme of the L-fucose and D-arabinose degradation pathways, respectively. [More information is available at EcoCyc: EG10348].
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Genomic context

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Sequence:
NC_000913.3 (2933041..2933688, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene flap endonuclease Neighboring gene L-1,2-propanediol oxidoreductase Neighboring gene L-fucose:H(+) symporter Neighboring gene L-fucose isomerase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Refined high-resolution structure of the metal-ion dependent L-fuculose-1-phosphate aldolase (class II) from Escherichia coli. Dreyer MK, et al. Acta Crystallogr D Biol Crystallogr, 1996 Nov 1. PMID 15299567
  2. The metabolism of L-fucose. II. The enzymatic cleavage of L-fuculose 1-phosphate. GHALAMBOR MA, et al. J Biol Chem, 1962 Aug. PMID 13898172
  3. Structures of l-fuculose-1-phosphate aldolase mutants outlining motions during catalysis. Joerger AC, et al. J Mol Biol, 2000 Nov 3. PMID 11054289
  4. Catalytic action of fuculose 1-phosphate aldolase (class II) as derived from structure-directed mutagenesis. Joerger AC, et al. Biochemistry, 2000 May 23. PMID 10821675
  5. L-fucose stimulates utilization of D-ribose by Escherichia coli MG1655 DeltafucAO and E. coli Nissle 1917 DeltafucAO mutants in the mouse intestine and in M9 minimal medium. Autieri SM, et al. Infect Immun, 2007 Nov. PMID 17709419, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A deletion of the fucA gene leads to induction of the proton-linked fucose transporter, FucP.
    Title: A route for fructose utilization by Escherichia coli involving the fucose regulon.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-fuculose-phosphate aldolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-fuculose-phosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within D-arabinose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-fucose catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-fucose catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in arabinose catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucose catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in monosaccharide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
L-fuculose-phosphate aldolase
NP_417280.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2933041..2933688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417280.1 L-fuculose-phosphate aldolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417280.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WZ48
    Conserved Domains (1) summary
    PRK08087
    Location:1 → 215
    PRK08087; L-fuculose-phosphate aldolase
Nucleotide Protein
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