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guaD guanine deaminase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947366, updated on 4-Apr-2024

Summary

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Gene symbol
guaD
Gene description
guanine deaminase
Primary source
ASAP:ABE-0009465
Locus tag
b2883
See related
ECOCYC:G7502
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2879; ygfP
Summary
YgfP has 36% identity to human guanine deaminase and similarity to allantoate amidohydrolase . [More information is available at EcoCyc: G7502].
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Genomic context

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Sequence:
NC_000913.3 (3025766..3027085)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative oxidoreductase Neighboring gene fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit Neighboring gene xanthine:H(+) symporter XanQ Neighboring gene guanine/hypoxanthine transporter GhxQ Neighboring gene putative electron transport protein YgfS Neighboring gene putative oxidoreductase YgfT

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bacterial ammeline metabolism via guanine deaminase. Seffernick JL, et al. J Bacteriol, 2010 Feb. PMID 20023034, Free PMC Article
  2. Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily. Shek R, et al. Biochemistry, 2019 Jul 30. PMID 31283204, Free PMC Article
  3. MEROPS: the peptidase database. Rawlings ND, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381862, Free PMC Article
  4. Identification, expression, and characterization of Escherichia coli guanine deaminase. Maynes JT, et al. J Bacteriol, 2000 Aug. PMID 10913105, Free PMC Article
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ammeline aminohydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in guanine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in guanine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanine deaminase
NP_417359.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3025766..3027085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417359.1 guanine deaminase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417359.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2A2XI39, A0A4P8BYR7, D6ICX1, D8A3V9, E1J3X8, E6BGC3, J7R8I1, V0A1R9
    Conserved Domains (1) summary
    PRK09228
    Location:6 → 438
    PRK09228; guanine deaminase; Provisional
Nucleotide Protein
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