U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

coaD pantetheine-phosphate adenylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947386, updated on 2-May-2024

Summary

Go to the top of the page Help
Gene symbol
coaD
Gene description
pantetheine-phosphate adenylyltransferase
Primary source
ASAP:ABE-0011875
Locus tag
b3634
See related
ECOCYC:EG11190
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK3624; kdtB; yicA
Summary
Phosphopantetheine adenylyltransferase (PPAT) catalyzes the transfer of an adenyly group from ATP to 4'-phosphopantetheine . [More information is available at EcoCyc: EG11190].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (3809825..3810304)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene KDO transferase Neighboring gene DNA-formamidopyrimidine glycosylase Neighboring gene 50S ribosomal subunit protein L33

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis. Miller JR, et al. J Bacteriol, 2007 Nov. PMID 17873050, Free PMC Article
  2. A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with coenzyme A. Izard T. J Bacteriol, 2003 Jul. PMID 12837781, Free PMC Article
  3. Inhibitors of phosphopantetheine adenylyltransferase. Zhao L, et al. Eur J Med Chem, 2003 Apr. PMID 12750020
  4. The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism. Izard T. J Mol Biol, 2002 Jan 25. PMID 11812124
  5. Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli. Izard T, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jun. PMID 10329792

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The steady-state kinetics and ligand binding properties of coaD in the biosynthesis of coenzyme A are reported.
    Title: Phosphopantetheine adenylyltransferase from Escherichia coli: investigation of the kinetic mechanism and role in regulation of coenzyme A biosynthesis.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pantetheine-phosphate adenylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pantetheine-phosphate adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within coenzyme A biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
pantetheine-phosphate adenylyltransferase
NP_418091.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3809825..3810304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418091.1 pantetheine-phosphate adenylyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418091.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AXD3
    Conserved Domains (1) summary
    PRK00168
    Location:3 → 159
    coaD; phosphopantetheine adenylyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.