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speA biosynthetic arginine decarboxylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947432, updated on 4-Apr-2024

Summary

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Gene symbol
speA
Gene description
biosynthetic arginine decarboxylase
Primary source
ASAP:ABE-0009634
Locus tag
b2938
See related
ECOCYC:EG10959
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2933
Summary
Biosynthetic arginine decarboxylase (SpeA) carries out the first step in putrescine biosynthesis, converting L-arginine to agmatine. [More information is available at EcoCyc: EG10959].
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Genomic context

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Sequence:
NC_000913.3 (3083935..3085911, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene metalloprotease LoiP Neighboring gene agmatinase Neighboring gene acid stress response protein YqgB Neighboring gene protein YqgG Neighboring gene protein YqgC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and purification of recombinant arginine decarboxylase (speA) from Escherichia coli. Song J, et al. Mol Biol Rep, 2010 Apr. PMID 19603287
  2. Post-translational and transcriptional regulation of polyamine biosynthesis in Escherichia coli. Panagiotidis CA, et al. Int J Biochem, 1994 Aug. PMID 8088419
  3. Partial separation of two pools of arginine in Escherichia coli; preferential use of exogenous rather than endogenous arginine for the biosynthesis of 1,4-diaminobutane. Tabor H, et al. J Biol Chem, 1969 Dec 10. PMID 4901370
  4. Biosynthetic arginine decarboxylase from Escherichia coli. Subunit interactions and the role of magnesium ion. Wu WH, et al. J Biol Chem, 1973 Mar 10. PMID 4571774
  5. Biosynthetic arginine decarboxylase from Escherichia coli. Purification and properties. Wu WH, et al. J Biol Chem, 1973 Mar 10. PMID 4571773

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables arginine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within arginine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arginine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within putrescine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in putrescine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in putrescine biosynthetic process from arginine IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within putrescine biosynthetic process from arginine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
biosynthetic arginine decarboxylase
NP_417413.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3083935..3085911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417413.1 biosynthetic arginine decarboxylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417413.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7A6ZU92
    Conserved Domains (1) summary
    COG1166
    Location:6 → 658
    SpeA; Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version

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